Invitrogen

EphB4 Polyclonal Antibody

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EphB4 Antibody (PA5-96240) in WB

Western blot analysis of EphB4 in extracts of Mouse liver. Samples were incubated with EphB4 Polyclonal antibody (Product # PA5-96240) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.

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产品信息

PA5-96240

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:200-1:2,000

产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant fusion protein containing a sequence corresponding to amino acids 300-540 of human EPHB4 (NP_0044353)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.39 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

RRID

AB_2808042

产品详细信息

Immunogen sequence: AVCQCRVGYF RARTDPRGAP CTTPPSAPRS VVSRLNGSSL HLEWSAPLES GGREDLTYAL RCRECRPGGS CAPCGGDLTF DPGPRDLVEP WVVVRGLRPD FTYTFEVTAL NGVSSLATGP VPFEPVNVTT DREVPPAVSD IRVTRSSPSS LSLAWAVPRA PSGAVLDYEV KYHEKGAEGP SSVRFLKTSE NRAELRGLKR GASYLVQVRA RSEAGYGPFG QEHHSQTQLD ESEGWREQLA L; Positive Samples: Mouse liver; Cellular Location: Cell membrane, Single-pass type I membrane protein

靶标信息

EPHB4 is a receptor tyrosine kinase that belongs to the ephrin receptor family. Members of the Eph family of kinases play important roles in diverse biological processes including nervous system development, angiogenesis and neural synapsis formation and maturation. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by EphB4 binds to ephrin-B2 and plays an essential role in vascular development.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: Developmental kinase 2; ephrin receptor EphB4; Ephrin type-B receptor 4; Hepatoma transmembrane kinase; mDK-2; soluble EPHB4 variant 1; soluble EPHB4 variant 2; soluble EPHB4 variant 3; Tyrosine kinase MYK-1; tyrosine-protein kinase receptor HTK; Tyrosine-protein kinase TYRO11

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基因别名: AI042935; EPHB4; HTK; MDK2; MYK1; TYRO11

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UniProt ID: (Human) P54760, (Mouse) P54761

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Entrez Gene ID: (Human) 2050, (Mouse) 13846

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