Search Thermo Fisher Scientific
图: 1 / 1
Antibody tested in Indirect ELISA
Epiregulin is an EGF-related growth factor that binds specifically to EGFR (ErbB1) and ErbB4, but not ErbB2 or ErbB3. It is expressed mainly in the placenta and peripheral blood leukocytes, as well as in certain carcinomas of the bladder, lung, kidney and colon. Epiregulin stimulates the proliferation of keratinocytes, hepatocytes, fibroblasts and vascular smooth muscle cells. It also inhibits the growth of several tumor-derived epithelial cell lines. Human Epiregulin is initially synthesized as a glycosylated 19.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce a 6.0 kDa mature secreted sequence.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Proepiregulin
基因别名: Ep; EPR; ER; EREG
UniProt ID: (Human) O14944
Entrez Gene ID: (Human) 2069
分子生物学功能:
growth factor