Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
图: 1 / 1
ErbB3 Chimeric Antibody (MA5-43072) in Neu
Microneutralization analysis of ErbB3 in MCF-7 human breast cancer cell line. Samples were incubated in ErbB3 monoclonal antibody (Product # MA5-43072). Assay conditions: IC50 is typically 15-75 ng/mL in the presence of 40 ng/mL Recombinant Human NRG1-beta 1/HRG1-beta 1.
产品信息
MA5-43072
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG1, kappa
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
mh908
抗原
Recombinant Human HER3/ErbB3 protein.
偶联物
形式
Liquid
浓度
1.62 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2912212
产品详细信息
Specificity: Human HER3/ErbB3. This product is a chimeric monoclonal antibody combining the constant domains of the human IgG1 molecule with mouse variable regions. The antibody was produced using recombinant antibody technology.
靶标信息
ErbB3 (c-erbB-3/HER-3) is a member of the type I family of growth factor receptors and binds to ligands in the heregulin family. ErbB3 is over-expressed in a variety of tumors in the prostate, bladder, breast, stomach, pancreas, and colon. Heregulin and EGF stimulate tyrosine phosphorylation of c-erbB-3 to different extents. The ErbB3 gene is located on the long arm of human chromosome 12 (12q13) and is transcribed into a 6. 2kb mRNA which is translated into a 160/180 kDa glycoprotein. The ErbB3 gene encodes a transmembrane receptor tyrosine kinase due to alternative splicing and forms heterodimers with other EGF receptor family members that have kinase activity. Heterodimerization leads to the activation of pathways that lead to cell proliferation or differentiation. Alternate transcriptional splice variants encoding different isoforms of ErbB3 have been characterized. One ErbB3 isoform lacks the intermembrane region, is secreted outside the cell, and acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: C-errB-3; human epidermal growth factor receptor 3; MDA BF 1; MGC88033; p180 ErbB3; p45 sErbB3; p85 sErbB3; Proto-oncogene-like protein c-ErbB-3; Receptor tyrosine-protein kinase erbB-3; Tyrosine kinase-type cell surface receptor HER3; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
基因别名: c-erbB-3; c-erbB3; ErbB-3; ERBB3; erbB3-S; HER3; LCCS2; MDA-BF-1; p180-ErbB3; p45-sErbB3; p85-sErbB3
UniProt ID: (Human) P21860
Entrez Gene ID: (Human) 2065
protein tyrosine kinase activity
transmembrane signaling receptor activity
Ras guanyl-nucleotide exchange factor activity
protein binding
ATP binding
growth factor binding
protein tyrosine kinase activator activity
neuregulin binding
identical protein binding
protein homodimerization activity
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
protein heterodimerization activity
transmembrane signal receptor
MAPK cascade
endocardial cushion development
negative regulation of cell adhesion
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
peripheral nervous system development
heart development
negative regulation of signal transduction
Schwann cell differentiation
phosphatidylinositol 3-kinase signaling
regulation of phosphatidylinositol 3-kinase signaling
positive regulation of phosphatidylinositol 3-kinase signaling
peptidyl-tyrosine phosphorylation
cranial nerve development
ERBB2 signaling pathway
wound healing
regulation of cell proliferation
negative regulation of neuron apoptotic process
positive regulation of GTPase activity
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
negative regulation of secretion
neuron apoptotic process
positive regulation of protein tyrosine kinase activity
positive regulation of calcineurin-NFAT signaling cascade
extrinsic apoptotic signaling pathway in absence of ligand
regulation of cell motility
