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产品信息
PA5-22707
产品规格
种属反应
Avian,
Dog,
Human,
Marsupial,
Mouse,
Non-human primate,
Rat,
Zebrafish
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Human FANCD2 fusion protein (N-terminal fragment).
偶联物
形式
Liquid
浓度
0.82 mg/mL
纯化类型
Affinity chromatography
保存液
PBS
内含物
no preservative
保存条件
4° C, store in dark
运输条件
Wet ice
RRID
AB_11153794
产品详细信息
In Western blot, this antibody should recognize a band at ~166 kDa (post-translationally modified form).
Additional bands may be seen at lower molecular weights.
靶标信息
FANCD2 (Fanconi anemia group D2 protein) is required for maintenance of chromosomal stability. It promotes accurate and efficient pairing of homologs during meiosis. FANCD2 is involved in the repair of DNA double-stranded breaks, both by homologous recombination and single-stranded annealing. It is required for the targeting/stabilization of BLM to non-centromeric abnormal structures induced by replicative stress. FANCD2 promotes BRCA2/FANCD1 loading onto damaged chromatin. Defects in the FANCD2 gene result in Fanconi anemia complementation group D2. This disorder affects all bone marrow elements resulting in anemia, leukopenia, and thrombopenia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DKFZp762A223; FACD2; Fancd2; Fanconi anemia complementation group D2; Fanconi anemia D2 protein; Fanconi anemia group D2 protein; Fanconi anemia group D2 protein homolog; Fanconi anemia, complementation group D2; FLJ23826; Protein FACD2
基因别名: 2410150O07Rik; AU015151; BB137857; FA-D2; FA4; FACD; FAD; FAD2; FANCD; FANCD2
UniProt ID: (Human) Q9BXW9, (Mouse) Q80V62, (Rat) Q6IV68
Entrez Gene ID: (Dog) 484659, (Human) 2177, (Mouse) 211651, (Rat) 312641, (Zebrafish) 394241
DNA repair
cellular response to DNA damage stimulus
cell cycle
synapsis
multicellular organism development
gamete generation
response to gamma radiation
intra-S DNA damage checkpoint
interstrand cross-link repair
negative regulation of apoptotic process
double-strand break repair involved in meiotic recombination
biological_process
