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NeoBiotechnologies
FGF23 (Fibroblast Growth Factor 23) Monoclonal Antibody (FGF23/4171)
产品信息
8074-MSM11-P1
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2b, kappa
分类
Monoclonal
类型
Antibody
克隆号
FGF23/4171
抗原
Recombinant fragment (around aa25-251) of human FGF23 protein.
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
Protein A/G
保存液
PBS with 0.05% BSA
内含物
0.05% sodium azide
保存条件
4° C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Antibody is stable for 24 months.
Positive Control: Human kidney tissue. Cellular Localization: Secreted (extracellular)
Specificity Comments: Fibroblast growth factor-1 (FGF-1), also designated acidic FGF, and fibroblast growth factor-2 (FGF-2), also designated basic FGF, are members of a family of growth factors that stimulate proliferation of cells of mesenchymal, epithelial and neuroectodermal origin. Additional members of the FGF family include the oncogenes FGF-3 (Int2) and FGF-4 (hst/Kaposi), FGF-5, FGF-6, FGF-7 (KGF), FGF-8 (AIGF), FGF-9 (GAF) and FGF-10 through FGF-23. Members of the FGF family share 30-55% amino acid sequence identity and similar gene structure, and are capable of transforming cultured cells when overexpressed in transfected cells. Cellular receptors for FGFs are members of a second multigene family, including four tyrosine kinases designated Flg (FGFR-1), Bek (FGFR-L), TKF and FGFR-3.
靶标信息
The protein encoded by this gene is a member of the fibroblast growth factor family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The product of this gene inhibits renal tubular phosphate transport. This gene was identified by its mutations associated with autosomal dominant hypophosphatemic rickets, an inherited phosphate wasting disorder. Abnormally high level expression of this gene was found in oncogenic hypophosphatemic osteomalacia, a phenotypically similar disease caused by abnormal phosphate metabolism. Mutations in this gene have also been shown to cause familial tumoral calcinosis with hyperphosphatemia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FGF; FGF-23; Fibroblast growth factor; Fibroblast growth factor 23; Phosphatonin; tumor-derived hypophosphatemia inducing factor; Tumor-derived hypophosphatemia-inducing factor
基因别名: ADHR; FGF23; FGFN; HPDR2; HYPF; PHPTC; UNQ3027/PRO9828
UniProt ID: (Human) Q9GZV9
Entrez Gene ID: (Human) 8074
MAPK cascade
fibroblast growth factor receptor signaling pathway
regulation of phosphate transport
positive regulation of vitamin D 24-hydroxylase activity
regulation of phosphatidylinositol 3-kinase signaling
peptidyl-tyrosine phosphorylation
cell differentiation
negative regulation of bone mineralization
cellular phosphate ion homeostasis
response to magnesium ion
phosphatidylinositol-3-phosphate biosynthetic process
vitamin D catabolic process
positive regulation of GTPase activity
cellular response to leptin stimulus
negative regulation of osteoblast differentiation
positive regulation of transcription, DNA-templated
phosphatidylinositol phosphorylation
negative regulation of hormone secretion
phosphatidylinositol-mediated signaling
phosphate ion homeostasis
positive regulation of ERK1 and ERK2 cascade
cellular response to vitamin D
cellular response to interleukin-6
cellular response to parathyroid hormone stimulus
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
response to sodium phosphate
