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产品信息
PA5-67212
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
偶联物
Unconjugated
形式
Liquid
浓度
0.3 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2662306
产品详细信息
Immunogen sequence: GDSFFDDPIPK PEKTYGLRKE PRKQAGSLAS LSDAPPLKSG LSSLAGAPSL KDSESKRGNT VL
Highest antigen sequence identity to the following orthologs - mouse 84%, rat 84%.
靶标信息
This gene encodes a largely hydrophilic protein postulated to be a leucine-rich protein family member. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. This gene is thought to play an important role in normal proliferation and differentiation of the erythroid lineage. Alternatively spliced transcript variants that encode different proteins have been identified.
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生物信息学
蛋白别名: Centrosomal protein 43; FGFR1 oncogene partner; fibroblast growth factor receptor 1 oncogene partner
基因别名: CEP43; FGFR1OP; FOP
UniProt ID: (Human) O95684
Entrez Gene ID: (Human) 11116
G2/M transition of mitotic cell cycle
negative regulation of protein kinase activity
positive regulation of cell proliferation
peptidyl-tyrosine phosphorylation
positive regulation of cell growth
positive regulation of cell migration
microtubule anchoring
negative regulation of protein tyrosine kinase activity
