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产品信息
PA5-34574
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A 19 amino acid peptide near the carboxy terminus of human FGFR3
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
4° C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2551926
产品详细信息
A suggested positive control is SK-N-SH cell lysate.
PA5-34574 can be used with blocking peptide PEP-1617.
靶标信息
FGFR3 is a member of the FGFR family of receptor tyrosine kinases. This family is known to regulate a host of cellular functions including angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, cellular differentiation, and tissue repair after injury. The FGFR family has also been implicated in a number of diseases including cancer, rheumatoid arthritis, and diabetic retinopathy. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: CD333; FGF Receptor; FGFR; FGFR-3; FGFR3deltaTM; Fibroblast growth factor receptor 3; fibroblast growth factor receptor 3 variant 4; heparin-binding growth factor receptor; hydroxyaryl-protein kinase; tyrosine kinase JTK4
基因别名: ACH; CD333; CEK2; Fgfr-3; FGFR3; Flg-2; FR3; HBGFR; HSFGFR3EX; JTK4; Mfr3; sam3
UniProt ID: (Human) P22607
Entrez Gene ID: (Human) 2261, (Rat) 84489, (Mouse) 14184
protein tyrosine kinase activity
fibroblast growth factor-activated receptor activity
Ras guanyl-nucleotide exchange factor activity
protein binding
ATP binding
1-phosphatidylinositol-3-kinase activity
fibroblast growth factor binding
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
growth factor activity
nucleotide binding
protein kinase activity
transmembrane receptor protein tyrosine kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
transmembrane signal receptor
MAPK cascade
skeletal system development
endochondral ossification
chondrocyte differentiation
endochondral bone growth
JAK-STAT cascade
cell-cell signaling
positive regulation of cell proliferation
fibroblast growth factor receptor signaling pathway
positive regulation of phospholipase activity
regulation of phosphatidylinositol 3-kinase signaling
peptidyl-tyrosine phosphorylation
bone mineralization
chondrocyte proliferation
phosphatidylinositol-3-phosphate biosynthetic process
positive regulation of tyrosine phosphorylation of Stat1 protein
positive regulation of tyrosine phosphorylation of Stat3 protein
positive regulation of MAPK cascade
positive regulation of GTPase activity
positive regulation of phosphatidylinositol 3-kinase activity
protein autophosphorylation
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
negative regulation of developmental growth
bone morphogenesis
positive regulation of ERK1 and ERK2 cascade
bone maturation
fibroblast growth factor receptor apoptotic signaling pathway
negative regulation of transcription from RNA polymerase II promoter
positive regulation of endothelial cell proliferation
morphogenesis of an epithelium
lens morphogenesis in camera-type eye
negative regulation of cell proliferation
oligodendrocyte development
substantia nigra development
central nervous system myelination
cell differentiation
forebrain development
positive regulation of protein ubiquitination
somatic stem cell population maintenance
post-anal tail morphogenesis
positive regulation of neuron apoptotic process
positive regulation of cell differentiation
negative regulation of mitotic nuclear division
negative regulation of smoothened signaling pathway
digestive tract morphogenesis
response to axon injury
negative regulation of astrocyte differentiation
inner ear development
negative regulation of epithelial cell proliferation
positive regulation of peptidyl-tyrosine phosphorylation
cartilage development
inner ear receptor cell differentiation
axonogenesis involved in innervation
alveolar secondary septum development
lens fiber cell development
epithelial cell fate commitment
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
cochlea development
positive regulation of canonical Wnt signaling pathway
protein phosphorylation
apoptotic process
phosphorylation
