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Invitrogen
FLT3 Monoclonal Antibody (R.257.6)
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Product Details
MA5-15138
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Monoclonal
Type
Antibody
Clone
R.257.6
Immunogen
Synthetic peptide corresponding to the sequence surrounding Ser740 of human FLT3
Conjugate
Form
Liquid
Concentration
44 µg/mL
Purification
Affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
<0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
It is not recommended to aliquot this antibody.
This antibody is not cross-reactive with related proteins.
Target Information
FLT3 is a tyrosine protein kinase that is a member of the growth factor receptor tyrosine kinase family. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD135; CD135 antigen; Fetal liver kinase 2; Fetal liver kinase-2; FL cytokine receptor; FLK-2; FLT-3; Fms-like tyrosine kinase 3; fms-related tyrosine kinase 3; growth factor receptor tyrosine kinase type III; OTTHUMP00000214829; Receptor-type tyrosine-protein kinase FLT3; RP11-153M24.3; Stem cell tyrosine kinase 1; STK-1; tyrosine-protein kinase FLT3; Tyrosine-protein kinase receptor flk-2
Gene Aliases: B230315G04; CD135; FLK-2; FLK2; Flt-3; FLT3; Ly72; STK1; wmfl
UniProt ID: (Human) P36888, (Mouse) Q00342
Entrez Gene ID: (Human) 2322, (Mouse) 14255
transmembrane receptor protein tyrosine kinase activity
cytokine receptor activity
vascular endothelial growth factor-activated receptor activity
protein binding
ATP binding
protein complex binding
glucocorticoid receptor binding
protein homodimerization activity
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
ubiquitin protein ligase binding
phosphatidylinositol 3-kinase binding
transmembrane signal receptor
leukocyte homeostasis
myeloid progenitor cell differentiation
pro-B cell differentiation
transmembrane receptor protein tyrosine kinase signaling pathway
positive regulation of cell proliferation
response to organonitrogen compound
positive regulation of phosphatidylinositol 3-kinase signaling
peptidyl-tyrosine phosphorylation
cytokine-mediated signaling pathway
hemopoiesis
B cell differentiation
organ regeneration
common myeloid progenitor cell proliferation
vascular endothelial growth factor signaling pathway
positive regulation of tyrosine phosphorylation of STAT protein
regulation of apoptotic process
positive regulation of MAP kinase activity
positive regulation of MAPK cascade
positive regulation of phosphatidylinositol 3-kinase activity
lymphocyte proliferation
protein autophosphorylation
cellular response to cytokine stimulus
cellular response to glucocorticoid stimulus
dendritic cell differentiation
positive regulation of protein phosphorylation
lymphoid progenitor cell differentiation
pro-T cell differentiation
protein phosphorylation
negative regulation of cell proliferation
phosphorylation
lymphocyte differentiation
cell differentiation
negative regulation of B cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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