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The antibody detects endogenous levels of total FMO5 protein.
Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Alternative splicing results in multiple transcript variants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Baeyer-Villiger monooxygenase 1; Dimethylaniline monooxygenase [N-oxide-forming] 5; Dimethylaniline oxidase 5; Flavin-containing monooxygenase 5; FMO 5; hBVMO1; Hepatic flavin-containing monooxygenase 5; NADPH oxidase
基因别名: 5033418D19Rik; AI195026; FMO5
UniProt ID: (Human) P49326, (Mouse) P97872
Entrez Gene ID: (Human) 2330, (Mouse) 14263
分子生物学功能: oxidoreductase oxygenase metabolite interconversion enzyme