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FOXA1 Antibody (PA5-90342) in IHC (P)
Immunohistochemistry analysis of FOXA1 in paraffin-embedded human breast cancer using. Samples were incubated with FOXA1 Polyclonal antibody (Product # PA5-90342) using a dilution of 1:100 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
产品信息
PA5-90342
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 263-472 of human FOXA1 (NP_0044872)
偶联物
形式
Liquid
浓度
0.84 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2806034
产品详细信息
Immunogen sequence: QKRFKCEKQP GAGGGGGSGS GGSGAKGGPE SRKDPSGASN PSADSPLHRG VHGKTGQLEG APAPGPAASP QTLDHSGATA TGGASELKTP ASSTAPPISS GPGALASVPA SHPAHGLAPH ESQLHLKGDP HYSFNHPFSI NNLMSSSEQQ HKLDFKAYEQ ALQYSPYGST LPASLPLGSA SVTTRSPIEP SALEPAYYQG VYSRPVLNTS; Positive Samples: A-549, MCF7, LO2, HeLa, Mouse lung; Cellular Location: Nucleus
靶标信息
This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Ci-fkh; fkd7; fkh; fork head domain; Forkhead box protein A1; forkhead-7; FoxA4a; hepatocyte nuclear factor 3 alpha (winged helix transcription factor); hepatocyte nuclear factor 3, alpha; Hepatocyte nuclear factor 3-alpha; HNF-3-alpha; HNF-3A; HNF3-alpha; HNF3alpha; MGC33105; MGC52590; MGC75967; pintallavis; TCF-3A; Transcription factor 3A; xfkh1; xfkh2
基因别名: FOXA1; Hnf-3a; HNF3A; Tcf-3a; TCF3A
UniProt ID: (Human) P55317, (Mouse) P35582, (Rat) P23512
Entrez Gene ID: (Human) 3169, (Mouse) 15375, (Rat) 25098
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription factor binding
protein domain specific binding
sequence-specific DNA binding
transcription regulatory region DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
double-stranded DNA binding
winged helix/forkhead transcription factor
negative regulation of transcription from RNA polymerase II promoter
chromatin remodeling
transcription from RNA polymerase II promoter
Notch signaling pathway
negative regulation of epithelial to mesenchymal transition
covalent chromatin modification
dorsal/ventral neural tube patterning
response to estradiol
positive regulation of intracellular estrogen receptor signaling pathway
hormone metabolic process
glucose homeostasis
positive regulation of neuron differentiation
positive regulation of smoothened signaling pathway
positive regulation of mitotic cell cycle
positive regulation of transcription from RNA polymerase II promoter
anatomical structure formation involved in morphogenesis
neuron fate specification
positive regulation of sequence-specific DNA binding transcription factor activity
epithelial tube branching involved in lung morphogenesis
lung epithelial cell differentiation
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
epithelial-mesenchymal signaling involved in prostate gland development
prostate gland epithelium morphogenesis
prostate gland stromal morphogenesis
epithelial cell maturation involved in prostate gland development
alveolar secondary septum development
dopaminergic neuron differentiation
respiratory basal cell differentiation
positive regulation of cell-cell adhesion mediated by cadherin
transcription, DNA-templated
regulation of transcription, DNA-templated
multicellular organism development
regulation of gene expression
chromatin modification
lung development
tube morphogenesis
regulation of cell cycle
connective tissue development
