Invitrogen

FOXA2 Polyclonal Antibody

查看其他24个FOXA2抗体

抗体检测数据 (3)

FOXA2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FOXA2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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FOXA2 Antibody (PA1-31936) in IHC (P)

Immunohistochemistry (Paraffin) analysis of FOXA2 in human prostate tissue using FOXA2 Polyclonal Antibody (Product # PA1-31936) at a dilution of 3.8 µg/mL. Antigen retrieval : citrate buffer pH 6.

FOXA2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FOXA2 Antibody in Western Blot (WB)

FOXA2 Antibody in Western Blot (WB)

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FOXA2 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry (Paraffin) analysis of FOXA2 in human prostate tissue using FOXA2 Polyclonal Antibody (Product # PA1-31936) at a dilution of 3.8 µg/mL. Antigen retrieval : citrate buffer pH 6.

FOXA2 Antibody in Western Blot (WB) — Western Blot analysis of FOXA2 was performed by loading 35 µg (in RIPA buffer) of human liver lysates. Proteins were transferred to a membrane and probed with a FOXA2 Polyclonal Antibody (Product # PA1-31936) at a dilution of 1 µg/mL.

FOXA2 Antibody in Western Blot (WB) — Western Blot analysis of FOXA2 was performed by loading 35 µg (in RIPA buffer) of rat lung lysates. Proteins were transferred to a membrane and probed with a FOXA2 Polyclonal Antibody (Product # PA1-31936) at a dilution of 1 µg/mL.

产品信息

PA1-31936

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1-3 µg/mL

-

免疫组化（石蜡） (IHC (P))

4-8 µg/mL

-

产品规格

种属反应

Human, Rat

宿主/亚型

Goat / IgG

分类

Polyclonal

类型

Antibody

抗原

synthetic peptide GVYSRPIMNSS, corresponding to amino acids 447-457 of Human FOXA 2.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Antigen affinity chromatography

保存液

TBS, pH 7.3, with 0.5% BSA

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2104994

产品详细信息

Recommended positive controls: The peptide used to generate this antibody is available for purchase (GTX25074-PEP)..

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

FOXA2 is a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin. They also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. FOXA2 has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: FKHL20; Forkhead box protein A2; hepatic nuclear factor-3-beta; hepatocyte nuclear factor 3, beta; Hepatocyte nuclear factor 3-beta; HNF-3-beta; HNF-3B; MGC19807; RONU; TCF-3B; Transcription factor 3B; WHN

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基因别名: FOXA2; HNF3B; Tcf-3b; TCF3B

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UniProt ID: (Human) Q9Y261, (Rat) P32182

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Entrez Gene ID: (Human) 3170, (Rat) 25099

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RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding transcription factor binding protein domain specific binding transcription regulatory region DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding double-stranded DNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding protein binding kinase binding sequence-specific DNA binding SMAD binding winged helix/forkhead transcription factor

参与通路

positive regulation of transcription from RNA polymerase II promoter by glucose negative regulation of transcription from RNA polymerase II promoter by glucose cell fate specification transcription, DNA-templated regulation of transcription from RNA polymerase II promoter adult locomotory behavior negative regulation of epithelial to mesenchymal transition covalent chromatin modification regulation of blood coagulation endocrine pancreas development negative regulation of glucokinase activity positive regulation of embryonic development negative regulation of sequence-specific DNA binding transcription factor activity positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of insulin secretion involved in cellular response to glucose stimulus response to interleukin-6 dopaminergic neuron differentiation primitive streak formation positive regulation of cell-cell adhesion mediated by cadherin positive regulation of gastrulation negative regulation of detection of glucose in utero embryonic development ectoderm formation regulation of transcription, DNA-templated transcription from RNA polymerase II promoter pattern specification process anatomical structure morphogenesis anterior/posterior pattern specification dorsal/ventral pattern formation regulation of gene expression chromatin modification regulation of lipid metabolic process regulation of steroid metabolic process cell differentiation in hindbrain dorsal/ventral neural tube patterning signal transduction involved in regulation of gene expression lung development somite rostral/caudal axis specification response to insulin negative regulation of neuron differentiation positive regulation of neuron differentiation positive regulation of smoothened signaling pathway positive regulation of transcription from RNA polymerase III promoter cell development anatomical structure formation involved in morphogenesis neuron fate specification epithelial tube branching involved in lung morphogenesis lung epithelial cell differentiation connective tissue development