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FOXH1 Antibody (PA5-72644) in WB
Western blot analysis of FOXH1 in various lysates. Samples were incubated with FOXH1 polyclonal antibody (Product # PA5-72644) using a dilution of 1:1,000 followed by Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at a dilution of 1:10,000. Lysates/proteins: 20 µg per lane. Lane 1: Zebrafish lysate; Lane 2: ZF4 whole cell lysate. Predicted band size: 52 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.
产品信息
PA5-72644
产品规格
种属反应
Zebrafish
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide between 313-334 amino acids from the Central region of DANRE foxh1
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A, Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2718498
靶标信息
FOXH1 is a member of the Forkhead-box (FOX) family of transcription factors and is the human homolog of Xenopus forkhead activin signal transducer-1. FOXH1 plays an important role in mediating TGF-beta/activin signals through its interaction with the SMAD2-SMAD4 complex. It is expressed primarily during early development and localizes in the cytoplasm until it forms a complex with the SMAD proteins at which time it translocates to the nucleus to positively or negatively affect gene expression.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: contains winged-helix domain; etID62177.12; Fast-1; Forkhead activin signal transducer 1; Forkhead box protein H1; Schmalspur protein; transcription factor; uncle freddy; unf
基因别名: fast; fast1; fe26b06; foxh1; schmalspur; SUR; wu:fe26b06; wu:fi30c08; wu:fi32b01
UniProt ID: (Zebrafish) Q9I9E1
Entrez Gene ID: (Zebrafish) 57930
transcription regulatory region sequence-specific DNA binding
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
sequence-specific DNA binding
SMAD binding
winged helix/forkhead transcription factor
negative regulation of transcription from RNA polymerase II promoter
blood vessel development
endoderm formation
mesoderm formation
heart looping
embryonic heart tube morphogenesis
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
determination of left/right symmetry
anatomical structure morphogenesis
dorsal/ventral pattern formation
specification of organ position
regulation of gene expression
notochord formation
prechordal plate formation
floor plate formation
hypothalamus development
cell differentiation
notochord development
somite rostral/caudal axis specification
floor plate development
cell migration involved in gastrulation
positive regulation of transcription from RNA polymerase II promoter
optic placode formation involved in camera-type eye formation
axial mesoderm morphogenesis
axial mesodermal cell fate specification
mesendoderm development
brain morphogenesis
Spemann organizer formation at the embryonic shield
embryonic heart tube left/right pattern formation
cellular response to cytokine stimulus
regulation of BMP signaling pathway involved in heart jogging
