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Invitrogen

FOXO3A Polyclonal Antibody

查看其他53个FOXO3A抗体
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说明书
实验方案
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产品信息

PA1-9042

应用
建议稀释比
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免疫印迹 (WB)

0.1-1 µg/mL
-

免疫组化（石蜡） (IHC (P))

5 µg/mL
-

免疫细胞化学 (ICC/IF)

1:100
-
产品规格

种属反应

Human

宿主/亚型

Goat / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide corresponding to the C terminus amino acids GAKQASSQSWVPG (aa 661-673).
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偶联物

Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Ammonium sulfate precipitation

保存液

TBS, pH 7.3, with 0.5% BSA

内含物

0.02% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2247228

产品详细信息

This antibody is predicted to react with bovine, canine, mouse, porcine and rat based on sequence homology.

This antibody was orginally validated as part of a Thermo Scientific Cellomics High Content Screening Kit. The antibody sold separately may have slightly different performance and may need to be further optimized for the best results.

This antibody is tested in Peptide ELISA: antibody detection limit dilution 8,000.

靶标信息

USP48 is a protein containing domains that associate it with the peptidase family C19, also known as family 2 of ubiquitin carboxyl-terminal hydrolases. Family members function as deubiquitinating enzymes, recognizing and hydrolyzing the peptide bond at the C-terminal glycine of ubiquitin. Enzymes in peptidase family C19 are involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: AF6q21 protein; forkhead box O3A; Forkhead box protein O3; forkhead homolog (rhabdomyosarcoma) like 1; Forkhead in rhabdomyosarcoma-like 1; forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1

基因别名: AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3; FOXO3A

UniProt ID: (Human) O43524

Entrez Gene ID: (Human) 2309

功能
core promoter binding transcription cofactor binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding beta-catenin binding protein kinase binding chromatin DNA binding sequence-specific DNA binding
参与通路
negative regulation of transcription from RNA polymerase II promoter ovulation from ovarian follicle initiation of primordial ovarian follicle growth antral ovarian follicle growth oocyte maturation regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter regulation of translation DNA damage response, signal transduction by p53 class mediator tumor necrosis factor-mediated signaling pathway cellular response to oxidative stress glucose homeostasis positive regulation of apoptotic process positive regulation of neuron apoptotic process positive regulation of erythrocyte differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of canonical Wnt signaling pathway neuronal stem cell population maintenance extrinsic apoptotic signaling pathway in absence of ligand regulation of neural precursor cell proliferation regulation of reactive oxygen species metabolic process
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