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产品信息
MA5-32523
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
JF1017
抗原
Synthetic peptide within human FOXP1 aa 615-653
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2809800
产品详细信息
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FLJ23741; Fork head related protein like B; fork head-related protein like B; Forkhead box protein P1; Forkhead box protein P1 (FOXP1); Forkhead-related transcription factor 1; Glutamine rich factor 1; glutamine-rich factor 1; Mac-1-regulated forkhead; MFH; MGC12942; MGC88572; MGC99551
基因别名: 12CC4; 3110052D19Rik; 4932443N09Rik; AI461938; AW494214; FOXP1; hFKH1B; HSPC215; MFH; QRF1
UniProt ID: (Human) Q9H334, (Rat) Q498D1, (Mouse) P58462
Entrez Gene ID: (Human) 27086, (Rat) 297480, (Mouse) 108655
RNA polymerase II transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific DNA binding
protein self-association
metal ion binding
androgen receptor binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
protein homodimerization activity
protein heterodimerization activity
negative regulation of transcription from RNA polymerase II promoter
in utero embryonic development
positive regulation of mesenchymal cell proliferation
pre-B cell differentiation
positive regulation of immunoglobulin production
negative regulation of B cell apoptotic process
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
heart development
skeletal muscle tissue development
motor neuron axon guidance
positive regulation of endothelial cell migration
ventral spinal cord development
osteoclast differentiation
lung development
response to lipopolysaccharide
regulation of tumor necrosis factor production
immunoglobulin V(D)J recombination
chemokine (C-C motif) ligand 2 secretion
osteoclast development
macrophage activation
monocyte activation
endothelial cell activation
sarcomere organization
regulation of monocyte differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of smooth muscle cell proliferation
smooth muscle tissue development
positive regulation of epithelial cell proliferation
regulation of interleukin-1 beta secretion
regulation of inflammatory response
cardiac muscle cell differentiation
regulation of cardiac muscle cell proliferation
negative regulation of androgen receptor signaling pathway
lung secretory cell differentiation
T follicular helper cell differentiation
cardiovascular system development
interleukin-21 secretion
regulation of defense response to bacterium
regulation of lung goblet cell differentiation
negative regulation of lung goblet cell differentiation
regulation of macrophage colony-stimulating factor production
regulation of endothelial tube morphogenesis
positive regulation of cardiac muscle cell differentiation
regulation of interleukin-12 secretion
transcription, DNA-templated
regulation of transcription, DNA-templated
anatomical structure morphogenesis
embryo development
