Invitrogen

FSHR Polyclonal Antibody

FSHR Antibody in Immunocytochemistry (ICC/IF)

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FSHR Antibody (PA5-120299) in ICC/IF

Immunofluorescence analysis of FSHR in HeLa cells. Samples were incubated with FSHR Polyclonal antibody (Product # PA5-120299) using a dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.

FSHR Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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产品信息

PA5-120299

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

免疫组化（石蜡） (IHC (P))

1:50-1:200

免疫细胞化学 (ICC/IF)

1:50-1:200

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant fusion protein containing a sequence corresponding to amino acids 631-695 of human FSHR (NP_000136.2).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.78 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.01% thimerosal

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

RRID

AB_2913871

产品详细信息

Positive test controls include: SKOV3, Mouse testis, Rat ovary. The target is usually found in the following locations: Cell membrane, Multi-pass membrane protein.

Immunogen sequence: KNFRRDFFIL LSKCGCYEMQ AQIYRTETSS TVHNTHPRNG HCSSAPRVTS GSTYILVPLS HLAQN

靶标信息

Follicle-Stimulating Hormone Receptor (FSHR) expression has been reported in ovary, uterus, and testis. ESTs have been isolated from testis libraries. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This turn-off activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

仅用于科研。不用于诊断过程。未经明确授权不得转售。