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FTO Antibody (PA5-85698) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of FTO was performed in DIV9 rat E18 primary hippocampal neuron cells fixed in 4% paraformaldehyde at RT for 15 min. Green: FTO Polyclonal Antibody (Product # PA5-85698) diluted at 1:500. Red: beta Tubulin 3/ Tuj1, stained by beta Tubulin 3/ Tuj1 antibody. Blue: Fluoroshield with DAPI.
产品信息
PA5-85698
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the center region of human FTO.
偶联物
形式
Liquid
浓度
2.05 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.025% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2792837
产品详细信息
Keep as concentrated solution.
Predicted reactivity: Mouse (83%), Rat (83%), Pig (85%), Rabbit (88%).
Positive Control: U87-MG, SK-N-SH, IMR32, SK-N-AS, 293T, HepG2.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
FTO is a novel protein and a member of the non-heme dioxygenase (Fe(II)-and 2-oxoglutarate-dependent dioxygenases) superfamily. Amino acid conservation patterns support this hypothesis and indicates that both 2-oxoglutarate and iron should be important for FTO function. Though not much is yet known about FTO, it is thought that the protein may somehow modify the activity of genes involved in metabolism and fat storage, which in turn may influence a person's risk of obesity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AlkB homolog 9; Alpha-ketoglutarate-dependent dioxygenase FTO; Fat mass and obesity-associated protein; fatso; m6A(m)-demethylase FTO; MGC5149; mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO; mRNA N(6)-methyladenosine demethylase FTO; protein fto; tRNA N1-methyl adenine demethylase FTO; U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO; U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO
基因别名: ALKBH9; BMIQ14; FTO; GDFD; KIAA1752; RGD1305121
UniProt ID: (Human) Q9C0B1, (Rat) Q2A121
Entrez Gene ID: (Human) 79068, (Rat) 291905
temperature homeostasis
DNA dealkylation involved in DNA repair
regulation of lipid storage
oxidative single-stranded DNA demethylation
oxidative single-stranded RNA demethylation
regulation of multicellular organism growth
RNA repair
regulation of respiratory system process
adipose tissue development
regulation of white fat cell proliferation
oxidative demethylation
DNA demethylation
regulation of brown fat cell differentiation
