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FUSIP1 Antibody (IHC-00642) in IHC
Detection of human FUSIP1 by immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-FUSIP1 (Cat. No. IHC-00642) used at a dilution of 1:100. Detection: Red-fluorescent goat anti-rabbit IgG-heavy and light chain cross-adsorbed Antibody DyLight® 594 Conjugated used at a dilution of 1:100.
产品信息
IHC-00642
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Region between residue 133 and 183 of human FUS interacting protein (serine/arginine-rich) 1.
偶联物
形式
Liquid
浓度
0.25 mg/mL
纯化类型
Antigen affinity chromatography
保存液
TBS, pH 7.0 to 8.0, with 0.1% BSA
内含物
0.09% sodium azide
保存条件
4° C
运输条件
Wet ice
产品详细信息
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Mouse, Rat, Bovine, Pig, Orangutan and White-tufted-ear marmoset
靶标信息
FUSIP1 is a member of the serine-arginine (SR) family of proteins, which is involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. This protein can influence splice site selection of adenovirus E1A pre-mRNA. It interacts with the oncoprotein TLS, and abrogates the influence of TLS on E1A pre-mRNA splicing.This gene product is a member of the serine-arginine (SR) family of proteins, which is involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. This protein can influence splice site selection of adenovirus E1A pre-mRNA. It interacts with the oncoprotein TLS, and abrogates the influence of TLS on E1A pre-mRNA splicing. Alternative splicing of this gene results in at least two transcript variants encoding different isoforms. In addition, transcript variants utilizing alternative polyA sites exist.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 40 kDa SR-repressor protein; FUS interacting protein (serine-arginine rich) 1; FUS-interacting protein (serine-arginine rich) 2; FUS-interacting serine-arginine-rich protein 1; neural-salient SR protein; protein phosphatase 1, regulatory subunit 149; serine-arginine repressor protein (40 kDa); Serine/arginine-rich splicing factor 10; Splicing factor SRp38; splicing factor, arginine/serine-rich 13; Splicing factor, arginine/serine-rich 13A; SR splicing factor 10; SRrp40; TASR; TLS-associated protein TASR; TLS-associated protein with Ser-Arg repeats; TLS-associated protein with SR repeats; TLS-associated serine-arginine protein; TLS-associated serine-arginine protein 1; TLS-associated serine-arginine protein 2; TLS-associated SR protein
基因别名: FUSIP1; FUSIP2; NSSR; PPP1R149; SFRS13; SFRS13A; SRp38; SRrp40; SRSF10; TASR; TASR1; TASR2
UniProt ID: (Human) O75494
Entrez Gene ID: (Human) 10772
spliceosomal tri-snRNP complex assembly
RNA splicing, via transesterification reactions
mRNA splicing, via spliceosome
regulation of transcription, DNA-templated
mRNA splice site selection
mRNA export from nucleus
cytosolic transport
regulation of mRNA splicing, via spliceosome
negative regulation of mRNA splicing, via spliceosome
