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FXYD1 Antibody (PA5-99971) in IHC (P)
Immunohistochemistry analysis of FXYD1 in mouse muscle tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with FXYD1 polyclonal antibody (Product # PA5-99971) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
产品信息
PA5-99971
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human FXYD1(Accession O00168), corresponding to amino acid residues I54-R92.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2818904
产品详细信息
Antibody detects endogenous levels of total FXYD1/PLM.
靶标信息
This gene encodes a member of the FXYD family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The protein encoded by this gene is a plasma membrane substrate for several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity and act as an accessory protein of Na,K-ATPase. Alternatively spliced transcript variants have been described.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FXYD domain-containing ion transport regulator 1; Phospholemman; Sodium Potassium ATPase; Sodium/potassium-transporting ATPase subunit FXYD1
基因别名: 0610012C17Rik; 1110006M24Rik; FXYD1; PLM; Pml
UniProt ID: (Human) O00168, (Mouse) Q9Z239, (Rat) O08589
Entrez Gene ID: (Human) 5348, (Mouse) 56188, (Rat) 58971
chloride transport
muscle contraction
regulation of heart contraction
ion transmembrane transport
regulation of cardiac muscle cell membrane potential
chloride transmembrane transport
positive regulation of sodium ion export from cell
regulation of cardiac conduction
regulation of sodium ion transmembrane transporter activity
transport
ion transport
positive regulation of organic acid transport
regulation of cytosolic calcium ion concentration
regulation of cardiac muscle cell contraction
positive regulation of inorganic anion transmembrane transport
brain development
