Search Thermo Fisher Scientific
- Contact Us
- Quick Order
-
Don't have an account ? Create Account
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
PA5-33560
Product Specifications
Species Reactivity
Bat,
Bovine,
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic 16 amino acid peptide from N-terminal extracellular domain of human FZD7 / Frizzled 7.
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2550940
Product Specific Information
Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Elephant, Bovine, Bat, Opossum (100%).
Target Information
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: frizzled 7, seven transmembrane spanning receptor; frizzled family receptor 7; frizzled homolog 7; Frizzled, drosophila, homolog of, 7; Frizzled-7; Fz-7; FzE3; hFz7; rizzled 7
Gene Aliases: FZD7; FzE3
UniProt ID: (Human) O75084
Entrez Gene ID: (Human) 8324, (Bovine) 524255
regulation of transcription, DNA-templated
G-protein coupled receptor signaling pathway
negative regulation of cell-substrate adhesion
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
stem cell population maintenance
neuron differentiation
T cell differentiation in thymus
substrate adhesion-dependent cell spreading
regulation of catenin import into nucleus
non-canonical Wnt signaling pathway via JNK cascade
positive regulation of phosphorylation
negative regulation of ectodermal cell fate specification
positive regulation of transcription, DNA-templated
positive regulation of JNK cascade
somatic stem cell division
positive regulation of epithelial cell proliferation involved in wound healing
canonical Wnt signaling pathway
Wnt signaling pathway, planar cell polarity pathway
mesenchymal to epithelial transition
cellular response to retinoic acid
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support