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Application
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Factor X/Xa Antibody (PA5-22059) in ICC/IF
Immunofluorescence analysis of methanol-fixed HeLa, using Factor X antibody (Product # PA5-22059) at 1:200 dilution.
产品信息
PA5-22059
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 33 and 312 of Factor X (Uniprot ID#P00742)
偶联物
Unconjugated
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 10% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_11151884
产品详细信息
Recommended positive controls: rat liver, human F10-transfected 293T cells.
Predicted reactivity: Rhesus Monkey (93%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
Factor X undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: coagulation factor 10; Coagulation factor X; factor Xa; prothrombinase; Stuart factor; Stuart-Prower factor
基因别名: F10; FX; FXA
UniProt ID: (Human) P00742, (Rat) Q63207
Entrez Gene ID: (Human) 2159, (Rat) 29243
