Invitrogen

Ferroportin Polyclonal Antibody

Ferroportin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Ferroportin Antibody (PA5-22993) in IHC (P)

Immunohistochemical analysis of Ferroportin in murine liver section. Samples were incubated in Ferroportin polyclonal antibody (Product # PA5-22993) using a dilution of 1:200. The representative image shows intense staining in the cellular membranes, whereas, a relatively milder postivity was observed in the cytoplasm of hepatocytes.

Ferroportin Antibody in Western Blot (WB)

Ferroportin Antibody in Flow Cytometry (Flow)

Ferroportin Antibody in Immunohistochemistry (IHC)

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产品信息

PA5-22993

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1 µg/mL

查看7篇已发表文章 7篇已发表文章

免疫组化 (IHC)

查看3篇已发表文章 3篇已发表文章

免疫组化（石蜡） (IHC (P))

1:200

查看1篇已发表文章 1篇已发表文章

免疫细胞化学 (ICC/IF)

1:200

查看1篇已发表文章 1篇已发表文章

流式细胞分析 (Flow)

1 µg/mL

产品规格

种属反应

Bovine, Human, Mouse, Pig, Rat

已发表种属

Human, Mouse, Rhesus monkey

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide made to an internal portion of the human protein (within residues 250-300).

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_11154326

产品详细信息

Suggested positive control: human intestine protein.

靶标信息

SLC40A1 is an iron-regulated transporter assumed to play roles in intestinal iron absorption and cellular iron release. It mediates iron efflux in the presence of ferroxidase. Defects in SLC40A1 cause hemochromatosis type 4 (HFE4), which is an autosomal dominant iron-loading disorder.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Induction of Hepcidin Expression in the Renal Cortex of Sickle Cell Disease Mice.

International journal of molecular sciences

Ahmad A,Kumari N,Afangbedji N,Nekhai S,Jerebtsova M

Published figure using Ferroportin polyclonal antibody (Product # PA5-22993) in Western Blot

Wed Jun 28 00:00:00 EDT 2023

Induction of Hepcidin Expression in the Renal Cortex of Sickle Cell Disease Mice.

International journal of molecular sciences

Ahmad A,Kumari N,Afangbedji N,Nekhai S,Jerebtsova M

Published figure using Ferroportin polyclonal antibody (Product # PA5-22993) in Western Blot

Wed Jun 28 00:00:00 EDT 2023

A static magnetic field improves bone quality and balances the function of bone cells with regulation on iron metabolism and redox status in type 1 diabetes.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Lv H,Wang Y,Zhen C,Liu J,Chen X,Zhang G,Yao W,Guo H,Wei Y,Wang S,Yang J,Shang P

PA5-22993 was used in Western Blot to show that SMF may act as a potential therapy for improving bone health in type 1 diabetes with regulation on iron homeostasis metabolism and redox status.

Sat Jul 01 00:00:00 EDT 2023

Transcriptomic analysis identified SLC40A1 as a key iron metabolism-related gene in airway macrophages in childhood allergic asthma.

Frontiers in cell and developmental biology

Wang Z,He Y,Cun Y,Li Q,Zhao Y,Luo Z

PA5-22993 was used in Immunocytochemistry-immunofluorescence to reveal the potential role of the iron metabolism-related gene SLC40A1 in the pathogenesis of childhood allergic asthma.

Tue May 02 00:00:00 EDT 2023

Effect of Chronic Cadmium Exposure on Brain and Liver Transporters and Drug-Metabolizing Enzymes in Male and Female Mice Genetically Predisposed to Alzheimer's Disease.

Drug metabolism and disposition: the biological fate of chemicals

Wang H,Zhang L,Xia Z,Cui JY

PA5-22993 was used in Western Blotting to investigate the Cd-ApoE interaction on the transcriptomic changes in the brains and livers of ApoE3/ApoE4 transgenic mice.

Sat Oct 01 00:00:00 EDT 2022

Knocking out alpha-synuclein in melanoma cells dysregulates cellular iron metabolism and suppresses tumor growth.

Scientific reports

Shekoohi S,Rajasekaran S,Patel D,Yang S,Liu W,Huang S,Yu X,Witt SN

Published figure using Ferroportin polyclonal antibody (Product # PA5-22993) in Western Blot

Thu Mar 04 00:00:00 EST 2021

Knocking out alpha-synuclein in melanoma cells dysregulates cellular iron metabolism and suppresses tumor growth.

Scientific reports

Shekoohi S,Rajasekaran S,Patel D,Yang S,Liu W,Huang S,Yu X,Witt SN

Published figure using Ferroportin polyclonal antibody (Product # PA5-22993) in Western Blot

Thu Mar 04 00:00:00 EST 2021

HDAC inhibition induces EMT and alterations in cellular iron homeostasis to augment ferroptosis sensitivity in SW13 cells.

Redox biology

Oliveira T,Hermann E,Lin D,Chowanadisai W,Hull E,Montgomery M

PA5-22993 was used in Western Blotting to establish SW13 cells as a model for exploring the link between iron and epithelial-to-mesenchymal transition.

Mon Nov 01 00:00:00 EDT 2021

Regular Physical Exercise Modulates Iron Homeostasis in the 5xFAD Mouse Model of Alzheimer's Disease.

International journal of molecular sciences

Belaya I,Kucháriková N,Górová V,Kysenius K,Hare DJ,Crouch PJ,Malm T,Atalay M,White AR,Liddell JR,Kanninen KM

PA5-22993 was used in Western Blotting to explore the effect of regular physical exercise on modulation of iron homeostasis in the brain and periphery of the 5xFAD mouse model of Alzheimer's disease.

Fri Aug 13 00:00:00 EDT 2021

β-Phenethyl Isothiocyanate Induces Cell Death in Human Osteosarcoma through Altering Iron Metabolism, Disturbing the Redox Balance, and Activating the MAPK Signaling Pathway.

Oxidative medicine and cellular longevity

Lv H,Zhen C,Liu J,Shang P

Published figure using Ferroportin polyclonal antibody (Product # PA5-22993) in Western Blot

Mon Jan 04 00:00:00 EST 2021

β-Phenethyl Isothiocyanate Induces Cell Death in Human Osteosarcoma through Altering Iron Metabolism, Disturbing the Redox Balance, and Activating the MAPK Signaling Pathway.

Oxidative medicine and cellular longevity

Lv H,Zhen C,Liu J,Shang P

Published figure using Ferroportin polyclonal antibody (Product # PA5-22993) in Western Blot

Mon Jan 04 00:00:00 EST 2021

Gestational diabetes mellitus affects placental iron homeostasis: Mechanism and clinical implications.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Zaugg J,Melhem H,Huang X,Wegner M,Baumann M,Surbek D,Körner M,Albrecht C

PA5-22993 was used in Immunohistochemistry to compare the expression of genes/proteins involved in iron homeostasis in placentae from GDM and healthy pregnancies (n = 11 each).

Mon Jun 01 00:00:00 EDT 2020

Iron Prevents Hypoxia-Associated Inflammation Through the Regulation of Nuclear Factor-κB in the Intestinal Epithelium.

Cellular and molecular gastroenterology and hepatology

Simmen S,Cosin-Roger J,Melhem H,Maliachovas N,Maane M,Baebler K,Weder B,Maeyashiki C,Spanaus K,Scharl M,de Vallière C,Zeitz J,Vavricka SR,Hausmann M,Rogler G,Ruiz PA

PA5-22993 was used in Immunohistochemistry to elucidate how iron influences the responses to hypoxia in the intestinal epithelium.

Mon May 06 00:00:00 EDT 2019

Systemic Iron Deficiency in a Nonhuman Primate Model of Endometriosis.

Comparative medicine

Atkins HM,Appt SE,Taylor RN,Torres-Mendoza Y,Lenk EE,Rosenthal NS,Caudell DL

Published figure using Ferroportin polyclonal antibody (Product # PA5-22993) in Immunofluorescence

Wed Aug 01 00:00:00 EDT 2018

Protein expression of fatty acid transporter 2 is polarized to the trophoblast basal plasma membrane and increased in placentas from overweight/obese women.

Placenta

Lager S,Ramirez VI,Gaccioli F,Jang B,Jansson T,Powell TL

PA5-22993 was used in Immunohistochemistry (Paraffin) to test the hypothesis that placental capacity to transport fatty acid is increased in overweight/obese women.

Fri Apr 01 00:00:00 EDT 2016

生物信息学

蛋白别名: CAR1; Cell adhesion regulator; duodenal-specific; Ferroportin; ferroportin 1; Ferroportin-1; iron regulated gene 1; Iron-regulated transporter 1; Metal transporter protein 1; metal transporting protein 1; MTP1; polycythaemia; SLC11A3 iron transporter; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3; solute carrier family 39 (iron-regulated transporter), member 1; solute carrier family 40 (iron-regulated transporter), member 1; Solute carrier family 40 member 1

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基因别名: Dusg; FPN; FPN1; Fpt1; HFE4; IREG1; MST079; MSTP079; MTP; MTP1; Ol5; Pcm; SLC11A3; Slc39a1; SLC40A1

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UniProt ID: (Human) Q9NP59, (Mouse) Q9JHI9, (Rat) Q923U9