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Invitrogen

Fibrillarin/FBLL1 Recombinant Rabbit Monoclonal Antibody (HL2588)

说明书
实验方案
技术支持
说明书
实验方案
技术支持

产品信息

MA5-56708

应用
建议稀释比
已发表文章

免疫印迹 (WB)

Assay-dependent
-

免疫组化（石蜡） (IHC (P))

Assay-dependent
-

免疫细胞化学 (ICC/IF)

Assay-dependent
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

HL2588

抗原

Recombinant fragment of human fibrillarin.

偶联物

Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

PBS

内含物

no preservative

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Dry ice (international)

靶标信息

Fibrillarin, encoded by the FBL gene (also known as FBLL1), is a highly conserved nucleolar protein that plays a critical role in the biogenesis of ribosomes. It is a component of the small nucleolar ribonucleoprotein (snoRNP) complexes and is primarily involved in the chemical modification of ribosomal RNA (rRNA), specifically in the methylation of the 2'-O-ribose residues of rRNA. This modification is essential for the proper processing and maturation of pre-rRNA into functional ribosomal subunits, which are crucial for protein synthesis within the cell. Fibrillarin is not only important for ribosome production but also for maintaining the structural integrity of the nucleolus, the site of ribosome assembly. Dysregulation or mutations in the FBL gene have been associated with various human diseases, including cancer, where altered ribosome biogenesis can contribute to uncontrolled cell proliferation. Additionally, fibrillarin has been studied in the context of autoimmune diseases, such as systemic sclerosis, where it can serve as an autoantigen. Understanding the function and regulation of fibrillarin is vital for insights into cellular growth, protein synthesis, and the pathogenesis of related diseases.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: 34 kDa nucleolar scleroderma antigen; 34-kD nucleolar scleroderma antigen; Histone-glutamine methyltransferase; Nucleolar protein 1; Protein-glutamine methyltransferase; RNA, U3 small nucleolar interacting protein 1; rRNA 2'-O-methyltransferase fibrillarin; rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1; U6 snRNA 2'-O-methyltransferase fibrillarin

基因别名: AI595406; AL022665; FBL; Fbll1; FIB; FIB1; FLRN; RGD1562841; RNU3IP1

UniProt ID: (Human) P22087, (Rat) P22509, (Mouse) P35550, (Mouse) Q80WS3

Entrez Gene ID: (Human) 2091, (Rat) 292747, (Mouse) 14113, (Mouse) 237730, (Rat) 363563

功能
TFIID-class transcription factor binding RNA binding protein binding rRNA methyltransferase activity poly(A) RNA binding ATPase binding histone-glutamine methyltransferase activity rRNA (adenine-N6,N6-)-dimethyltransferase activity protein C-terminal carboxyl O-methyltransferase activity tRNA (guanine-N2-)-methyltransferase activity methyltransferase activity C-methyltransferase activity N-methyltransferase activity O-methyltransferase activity S-methyltransferase activity RNA methyltransferase activity mRNA methyltransferase activity tRNA methyltransferase activity protein methyltransferase activity 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity rRNA (uridine-2'-O-)-methyltransferase activity rRNA (adenine-N6-)-methyltransferase activity DNA-methyltransferase activity tRNA (guanine-N1-)-methyltransferase activity rRNA (cytosine-C5-)-methyltransferase activity selenocysteine methyltransferase activity arginine N-methyltransferase activity protein-arginine N-methyltransferase activity lysine N-methyltransferase activity protein-lysine N-methyltransferase activity tRNA (uracil) methyltransferase activity tRNA (guanine) methyltransferase activity tRNA (adenine) methyltransferase activity tRNA (cytosine) methyltransferase activity tRNA (cytosine-5-)-methyltransferase activity tRNA (adenine-N1-)-methyltransferase activity rRNA (adenine) methyltransferase activity rRNA (cytosine) methyltransferase activity rRNA (guanine) methyltransferase activity rRNA (uridine) methyltransferase activity transferase activity protein C-terminal leucine carboxyl O-methyltransferase activity 1-phenanthrol methyltransferase activity protein-arginine N5-methyltransferase activity methylarsonite methyltransferase activity dimethylarsinite methyltransferase activity 4,5-dihydroxybenzo(a)pyrene methyltransferase activity 1-hydroxypyrene methyltransferase activity 1-hydroxy-6-methoxypyrene methyltransferase activity demethylmenaquinone methyltransferase activity cobalt-precorrin-6B C5-methyltransferase activity cobalt-precorrin-7 C15-methyltransferase activity cobalt-precorrin-5B C1-methyltransferase activity cobalt-precorrin-3 C17-methyltransferase activity dimethylamine methyltransferase activity hydroxyneurosporene-O-methyltransferase activity tRNA (adenine-57, 58-N(1)-) methyltransferase activity methylamine-specific methylcobalamin:coenzyme M methyltransferase activity trimethylamine methyltransferase activity methanol-specific methylcobalamin:coenzyme M methyltransferase activity monomethylamine methyltransferase activity P-methyltransferase activity Se-methyltransferase activity 2-phytyl-1,4-naphthoquinone methyltransferase activity tRNA (uracil-2'-O-)-methyltransferase activity tRNA (cytosine-2'-O-)-methyltransferase activity phosphomethylethanolamine N-methyltransferase activity tRNA (cytosine-3-)-methyltransferase activity rRNA (cytosine-2'-O-)-methyltransferase activity rRNA (cytosine-N4-)-methyltransferase activity trihydroxyferuloyl spermidine O-methyltransferase activity RNA processing factor
参与通路
box C/D snoRNA 3'-end processing osteoblast differentiation rRNA processing tRNA processing rRNA methylation snoRNA localization histone glutamine methylation RNA processing snoRNA metabolic process methylation
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