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Fra1 Antibody (PA5-115252) in IHC (P)
Immunohistochemistry analysis of Fra1 in mouse testis tissue. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-115252) at a dilution of 1:100. Secondary staining was applied with HRP conjugated anti-Rabbit.
产品信息
PA5-115252
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human FOSL1(Accession P15407), corresponding to amino acid residues R111-L161.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2899888
产品详细信息
Antibody detects endogenous levels of total FRA1.
靶标信息
The v-Fos oncogene was initially detected in two independent murine osteosarcoma virus isolates and an avian nephroblastoma virus. Members of the c-Fos gene family, including c-Fos, Fos B, Fra-1 and Fra-2, encode nuclear phosphoproteins that are rapidly and transiently induced by a variety of agents and function as transcriptional regulators for several genes. In contrast to c-Jun proteins, which form homo- and heterodimers that bind to specific DNA response elements, c-Fos proteins are only active as heterodimers with members of the Jun gene family. In addition, selected ATF/CREB family members can form leucine zipper dimers with Fos and Jun. Different dimers exhibit differential specificity and affinity for AP-1 and CRE sites.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FOS like 1, AP-1 trancription factor subunit; FOS like antigen 1; FOS-like antigen 1; FOS-like antigen-1; Fos-related antigen 1; FRA-1; HGNC:13718
基因别名: AW538199; FOSL1; FRA; Fra-1; FRA1
UniProt ID: (Human) P15407, (Mouse) P48755, (Rat) P10158
Entrez Gene ID: (Human) 8061, (Mouse) 14283, (Rat) 25445
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
protein binding
RNA polymerase II regulatory region sequence-specific DNA binding
DNA binding
sequence-specific DNA binding
basic leucine zipper transcription factor
in utero embryonic development
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
chemotaxis
cellular defense response
vitellogenesis
female pregnancy
learning
positive regulation of cell proliferation
negative regulation of cell proliferation
response to mechanical stimulus
response to virus
response to gravity
cellular response to extracellular stimulus
response to progesterone
response to cytokine
response to drug
response to hydrogen peroxide
positive regulation of apoptotic process
positive regulation of cell cycle
positive regulation of transcription from RNA polymerase II promoter
positive regulation of sequence-specific DNA binding transcription factor activity
response to corticosterone
response to cAMP
placenta blood vessel development
pri-miRNA transcription from RNA polymerase II promoter
positive regulation of DNA-templated transcription, initiation
regulation of transcription, DNA-templated
response to organic cyclic compound
