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Immunogen sequence: METVQELIPL AKEMMAQKRK GKMVKLYVLG SVLALFGVVL GLMETVCSPF TAARRLRDQE AAVAELQAAL ERQALQKQAL QEKGKQQDTV LGGRALSNRQ; Positive Samples: K-562, 293T; Cellular Location: Mitochondrion
The G(0)-G(1) switch gene 2 (G0S2) codes for a mitochondrial protein that is important in apoptosis, lipolysis, and triacylglycerol hydrolysis. In adipocytes, G0S2 binds to adipose triglyceride lipase and decreases the breakdown of lipid droplets. In Crohn's colitis, the presence of G0S2 is increased in correlation to the amount of non-converted lipid in waste. In squamous lung cancer, mutations in the G0S2 gene are common. In breast cancer, epigenetic silencing of G0S2 occurs, and normal apoptotic regulation of aberrant cells is negatively impacted. However, when G0S2 is not epigenetically modified, it is the best mediator of the Bcl-2/Bax heterodimer, resulting in apoptosis of cancerous cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: G0/G1 switch protein 2; G0/G1 switch regulatory protein 2; G0/G1switch 2; Putative lymphocyte G0/G1 switch gene; RP1-28O10.2
基因别名: G0S2
UniProt ID: (Human) P27469
Entrez Gene ID: (Human) 50486