Product References
Cytosolic stress granules relieve the ubiquitin-proteasome system in the nuclear compartment.
The EMBO journal
Xu S,Gierisch ME,Schellhaus AK,Poser I,Alberti S,Salomons FA,Dantuma NP
PA5-29455 was used in Western Blot to reveal that stress granules play an important role in the sequestration of cytosolic misfolded proteins, thereby preventing these proteins from accumulating in the nucleus, where they would otherwise infringe nuclear proteostasis.
Wed Feb 01 00:00:00 UTC 2023
Identification of a novel compound that simultaneously impairs the ubiquitin-proteasome system and autophagy.
Autophagy
Giovannucci TA,Salomons FA,Stoy H,Herzog LK,Xu S,Qian W,Merino LG,Gierisch ME,Haraldsson M,Lystad AH,Uvell H,Simonsen A,Gustavsson AL,Vallin M,Dantuma NP
Published figure using G3BP1 polyclonal antibody (Product # PA5-29455) in Immunocytochemistry
Fri Jul 01 00:00:00 UTC 2022
Small-molecule modulators of INAVA cytosolic condensate and cell-cell junction assemblies.
The Journal of cell biology
Chang D,Luong P,Li Q,LeBarron J,Anderson M,Barrett L,Lencer WI
Published figure using G3BP1 polyclonal antibody (Product # PA5-29455) in Immunocytochemistry
Mon Sep 06 00:00:00 UTC 2021
RNA-Induced Conformational Switching and Clustering of G3BP Drive Stress Granule Assembly by Condensation.
Cell
Guillén-Boixet J,Kopach A,Holehouse AS,Wittmann S,Jahnel M,Schlüßler R,Kim K,Trussina IREA,Wang J,Mateju D,Poser I,Maharana S,Ruer-Gruß M,Richter D,Zhang X,Chang YT,Guck J,Honigmann A,Mahamid J,Hyman AA,Pappu RV,Alberti S,Franzmann TM
PA5-29455 was used in Immunocytochemistry-immunoflourescence to propose that condensation coupled to conformational rearrangements and heterotypic multivalent interactions may be a general principle underlying RNP granule assembly.
Thu Apr 16 00:00:00 UTC 2020
RNA-Induced Conformational Switching and Clustering of G3BP Drive Stress Granule Assembly by Condensation.
Cell
Guillén-Boixet J,Kopach A,Holehouse AS,Wittmann S,Jahnel M,Schlüßler R,Kim K,Trussina IREA,Wang J,Mateju D,Poser I,Maharana S,Ruer-Gruß M,Richter D,Zhang X,Chang YT,Guck J,Honigmann A,Mahamid J,Hyman AA,Pappu RV,Alberti S,Franzmann TM
PA5-29455 was used in Immunocytochemistry-immunoflourescence to propose that condensation coupled to conformational rearrangements and heterotypic multivalent interactions may be a general principle underlying RNP granule assembly.
Thu Apr 16 00:00:00 UTC 2020
TDP-43, a protein central to amyotrophic lateral sclerosis, is destabilized by tankyrase-1 and -2.
Journal of cell science
McGurk L,Rifai OM,Bonini NM
PA5-29455 was used in Immunocytochemistry-immunoflourescence to study how tankyrase 1 and 2 activity modulates TDP-43 in the disease context of amyotrophic lateral sclerosis.
Tue Jun 23 00:00:00 UTC 2020
TDP-43, a protein central to amyotrophic lateral sclerosis, is destabilized by tankyrase-1 and -2.
Journal of cell science
McGurk L,Rifai OM,Bonini NM
PA5-29455 was used in Immunocytochemistry-immunoflourescence to study how tankyrase 1 and 2 activity modulates TDP-43 in the disease context of amyotrophic lateral sclerosis.
Tue Jun 23 00:00:00 UTC 2020
Human Insulin Growth Factor 2 mRNA Binding Protein 2 Increases MicroRNA 33a/b Inhibition of Liver ABCA1 Expression and Alters Low-Density Apolipoprotein Levels in Mice.
Molecular and cellular biology
Yang M,Gallo-Ebert C,Hayward M,Liu W,McDonough V,Nickels JT
PA5-29455 was used in Western Blotting to support the hypothesis that IGF2BP2 has an important role in maintaining lipid homeostasis through its modulation of ABCA1 expression, as its overexpression or loss leads to dyslipidemia.
Wed Jul 29 00:00:00 UTC 2020
An aberrant phase transition of stress granules triggered by misfolded protein and prevented by chaperone function.
The EMBO journal
Mateju D,Franzmann TM,Patel A,Kopach A,Boczek EE,Maharana S,Lee HO,Carra S,Hyman AA,Alberti S
PA529455 was used in immunocytochemistry to characterize the components of stress granules
Wed Jun 14 00:00:00 UTC 2017