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Invitrogen
GABRB2 Polyclonal Antibody
高级验证
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
产品信息
PA5-64331
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2641813
产品详细信息
Immunogen sequence: STLEIKNEMA TSEAVMGLGD PRSTMLAYDA SSIQYRKAGL PRHSFGRNAL ERHVAQKKSR
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.
靶标信息
GAD-65 and GAD-67, glutamate decarboxylases, function to catalyze the production of GABA (gamma-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl- conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct. Members of the GABAA receptor family include GABAA Rα1-6, GABAA R β1-3, GABAA Rγ1-3, GABAA Rδ, GABAA Rε, GABAA Rρ1 and GABAA Rρ2. The GABAB family is composed of GABAB R1α and GABAB R1β. GABA transporters have also been identified and include GABA T-1, GABA T-2 and GABA T-3 (also designated GAT-1, -2, and -3). The GABA transporters function to terminate GABA action.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: GABA(A) receptor subunit beta-2; GABAAR subunit beta-2; GABAARbeta2; gamma-aminobutyric acid; gamma-aminobutyric acid A receptor beta 2; Gamma-aminobutyric acid receptor subunit beta-2; MGC119386; MGC119388; MGC119389
基因别名: GABRB2
UniProt ID: (Human) P47870
Entrez Gene ID: (Human) 2561
transport
gamma-aminobutyric acid signaling pathway
chemical synaptic transmission
sensory perception of sound
ion transmembrane transport
negative regulation of neuron apoptotic process
synaptic transmission, GABAergic
inner ear receptor cell development
innervation
cellular response to histamine
cochlea development
chloride transmembrane transport
