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GABRB3 Antibody (PA5-87565) in WB
Western blot analysis of GABRB3 in extracts of various cell lines. Samples were incubated with GABRB3 Polyclonal antibody (Product # PA5-87565) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.
产品信息
PA5-87565
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 330-460 of human GABRB3 (NP_0008051)
偶联物
形式
Liquid
浓度
0.58 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2804258
产品详细信息
Immunogen sequence: IFFGRGPQRQ KKLAEKTAKA KNDRSKSESN RVDAHGNILL TSLEVHNEMN EVSGGIGDTR NSAISFDNSG IQYRKQSMPR EGHGRFLGDR SLPHKKTHLR RRSSQLKIKI PDLTDVNAID RWSRIVFPFT F; Positive Samples: SH-SY5Y, A-549, BT-474; Cellular Location: Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse
靶标信息
Gamma-amino butyric acid (GAMA) is a strong inhibitor of neuron transmission and is found throughout the central nervous system. GABA is formed by the decarboxylation of glutamate, resulting in the formation of one of two distinct types; GABA-A or GABA-B.The binding of GABA to GABA-A receptors results in the increase transportation of chlorine ions into the neuron. This influx results in signal transmission repression. Studies have shown that if cell to cell signaling goes unchecked due to a lack of GABA, a system overload can resulting in blackouts, rapid body contractions, seizures and epilepsy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: GABA(A) receptor subunit beta-3; GABA-alpha receptor beta-2 subunit; GABAA receptor beta-3 subunit; GABAAR subunit beta-3; GABR B3; gamma-aminobutyric acid; gamma-aminobutyric acid (GABA) A receptor, beta 3; gamma-aminobutyric acid A receptor beta 3; Gamma-aminobutyric acid receptor subunit beta-3; MGC9051
基因别名: ECA5; GABRB3
UniProt ID: (Human) P28472
Entrez Gene ID: (Human) 2562
transport
signal transduction
sensory perception of sound
ion transmembrane transport
negative regulation of neuron apoptotic process
palate development
inhibitory postsynaptic potential
inner ear receptor cell development
innervation
cellular response to histamine
cochlea development
chloride transmembrane transport
