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GADD34 Antibody (MA5-36129) in IHC (P)
Immunohistochemical analysis of GADD34 in paraffin-embedded human prostate carcinoma tissue using a monoclonal antibody (Product #MA5-36129). The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 8.0-8.4) for 20 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with the primary antibody (1:100) for... View More
产品信息
MA5-36129
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
A4D7
抗原
Synthetic peptide within Human GADD34 aa 1-50
偶联物
形式
Liquid
浓度
2 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.4, with 0.2% BSA, 50% glycerol
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2890311
靶标信息
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with apoptosis following ionizing radiation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Growth arrest and DNA damage-inducible protein GADD34; growth arrest and DNA-damage-inducible 34; Myeloid differentiation primary response protein MyD116 homolog; PR15A; Protein phosphatase 1 regulatory subunit 15A; protein phosphatase 1, regulatory (inhibitor) subunit 15A; protein phosphatase 1, regulatory subunit 15A
基因别名: GADD34; PPP1R15A
UniProt ID: (Human) O75807
Entrez Gene ID: (Human) 23645
positive regulation of protein phosphorylation
apoptotic process
cellular response to DNA damage stimulus
cell cycle arrest
aging
negative regulation of cell proliferation
negative regulation of peptidyl-threonine phosphorylation
negative regulation of protein processing
endoplasmic reticulum unfolded protein response
positive regulation of translational initiation in response to stress
negative regulation of phosphoprotein phosphatase activity
positive regulation of phosphoprotein phosphatase activity
cellular response to UV
response to endoplasmic reticulum stress
negative regulation of protein dephosphorylation
cellular response to drug
response to immobilization stress
regulation of translational initiation by eIF2 alpha dephosphorylation
response to cocaine
positive regulation of apoptotic process
regulation of angiogenesis
negative regulation of cell death
regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
peptidyl-serine dephosphorylation
protein localization to endoplasmic reticulum
cellular response to antibiotic
cellular response to carbohydrate stimulus
cellular response to methyl methanesulfonate
cellular response to calcium ion starvation
response to environmental enrichment
cellular response to oxygen-glucose deprivation
positive regulation of peptidyl-serine dephosphorylation
negative regulation of PERK-mediated unfolded protein response
negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation
cellular response to desipramine
cellular response to cordycepin
cellular response to gold(3+)
cellular response to methamphetamine hydrochloride
negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
