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产品信息
OPA1-15410
产品规格
种属反应
Human
已发表种属
Sheep
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide (KLH conjugated) to the 7th transmembrane domain.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.1% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2109152
产品详细信息
By immunohistochemistry, OPA1-15410 detects GalR2 in formalin fixed, paraffin embedded human tissues.
靶标信息
GalR2 expression has been documented widely in the brain and in peripheral tissues including small intestine, heart, kidney, and liver. Localization data from rat CNS indicate high levels of expression in dorsal root ganglia, amygdala, and Purkinje neurons. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This "turn-off" activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Gal receptor 2; Gal-2 receptor; Gal-r2; GAL2-R; Galanin r2 receptor; Galanin receptor type 2; Galanin-2 receptor; MGC125983; MGC125984
基因别名: GAL2-R; GALNR2; GALR-2; GALR2
UniProt ID: (Human) O43603
Entrez Gene ID: (Human) 8811
muscle contraction
cell surface receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
negative regulation of adenylate cyclase activity
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
neuropeptide signaling pathway
chemical synaptic transmission
multicellular organism development
digestion
learning or memory
feeding behavior
neuron projection development
inositol phosphate metabolic process
positive regulation of transcription from RNA polymerase II promoter
phosphatidylinositol metabolic process
positive regulation of large conductance calcium-activated potassium channel activity
