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GATA5 Antibody (PA5-47262) in ICC/IF
Immunocytochemistry analysis of GATA5 in immersion fixed HepG2 human hepatocellular carcinoma cell line. Samples were incubated in GATA5 polyclonal antibody (Product # PA5-47262) using a dilution of 1.7 µg/mL for 3 hours at room temperature followed by NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red) and counterstained with DAPI (blue). Specific staining was localized to nuclei.
产品信息
PA5-47262
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E. coli-derived recombinant human GATA-5 Met1-Ala397
偶联物
形式
Lyophilized
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2605675
产品详细信息
In direct ELISAs, less than 1% cross-reactivity with recombinant human (rh) GATA-1, rhGATA-2, rhGATA-3, rhGATA-4, and rhGATA-6 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
靶标信息
GATA binding factor 5 is a transcription regulator involved in embryonic development. In addition, the protein encoded by this gene contains two GATA-type zinc fingers and is known to bind to hepatocyte nuclear factor-1alpha (HNF-1alpha). This interaction is essential for cooperative activation of the intestinal lactase-phlorizin hydrolase promoter. GATA-5 may be involved in the establishment of cardiac smooth muscle cell diversity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: GATA binding factor-5; GATA-binding factor 5; GATA-binding protein 5; Transcription factor GATA-5
基因别名: bB379O24.1; GATA5; GATAS
UniProt ID: (Human) Q9BWX5
Entrez Gene ID: (Human) 140628
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II transcription factor binding
enhancer sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
zinc ion binding
transcription regulatory region DNA binding
DNA-binding transcription factor
transcription from RNA polymerase II promoter
heart development
blood coagulation
organ morphogenesis
cell fate commitment
positive regulation of transcription from RNA polymerase II promoter
cell development
anatomical structure formation involved in morphogenesis
intestinal epithelial cell differentiation
cellular response to BMP stimulus
