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产品信息
H00002629-M01
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
2E2
抗原
GBA (NP_000148, 146 a.a. approximately 235 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: SYFSEEGIGY NIIRVPMASC DFSIRTYTYA DTPDDFQLHN FSLPEEDTKL KIPLIHRALQ LAQRPVSLLA SPWTSPTWLK TNGAVNGKGS
靶标信息
GBA encodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glycosylceramide, an intermediate in glycolipid metabolism. Mutations in this gene cause Gaucher disease, a lysosomal storage disease characterized by an accumulation of glucocerebrosides. A related pseudogene is approximately 12 kb downstream of this gene on chromosome 1. Alternative splicing results in multiple transcript variants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Acid beta-glucosidase; Alglucerase; Beta-GC; Beta-glucocerebrosidase; Beta-glucosylceramidase 1; Cholesterol glucosyltransferase; Cholesteryl-beta-glucosidase; D-glucosyl-N-acylsphingosine glucohydrolase; glucosidase, beta, acid; Glucosylceramidase beta 1; glucosylceramidase-like protein; Imiglucerase; Lysosomal acid GCase; Lysosomal acid glucosylceramidase; Lysosomal cholesterol glycosyltransferase; Lysosomal galactosylceramidase; lysosomal glucocerebrosidase; Lysosomal glycosylceramidase; SGTase
基因别名: GBA; GBA1; GC; GCB; GLUC
UniProt ID: (Human) P04062
Entrez Gene ID: (Human) 2629
carbohydrate metabolic process
glucosylceramide catabolic process
glycosphingolipid metabolic process
cellular response to starvation
response to pH
positive regulation of macroautophagy
regulation of macroautophagy
termination of signal transduction
regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of interleukin-6 production
regulation of water loss via skin
response to testosterone
positive regulation of protein dephosphorylation
negative regulation of MAP kinase activity
skin morphogenesis
response to estrogen
sphingosine biosynthetic process
ceramide biosynthetic process
negative regulation of inflammatory response
response to glucocorticoid
cellular response to tumor necrosis factor
response to thyroid hormone
positive regulation of proteolysis involved in cellular protein catabolic process
