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产品信息
PA5-23509
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A portion of amino acids 500-550 of human GBP1
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS with 0.05% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2541009
靶标信息
GBP1 or guanlyate binding protein 1 is a 68 kDa GTPase and member of the GTPase1 family of molecules. GBP1 expression is induced by Interferon g as well as other inflammatory cytokines including IL-1a, IL-1b and TNF-a. Induction of GBP1 expression by poly I:C, a prototypical TLR3 ligand, as well as GBP1 expression dependency on NF-kB and IFNa response elements implicate TLR pathway involvement. Inversely proportional expression of GBP1 and MMP-1 as well as other related molecules to adhesion and migration show a clear functional role of GBP1 in suppressing angiogenesis and migration especially of endothelial cells. As a regulatory molecule it is centrally involved in signal transduction of inflammatory and cell migration networks.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: GBP-1; GTP-binding protein 1; Guanine nucleotide-binding protein 1; guanylate binding protein 1, interferon-inducible; guanylate binding protein 1, interferon-inducible, 67kDa; guanylate nucleotide binding protein 1; Guanylate-binding protein 1; huGBP-1; interferon-gamma-inducible protein MAG-1; Interferon-induced guanylate-binding protein 1
基因别名: Gbp-1; GBP1; Mag-1; Mpa-1; Mpa1
UniProt ID: (Human) P32455
Entrez Gene ID: (Human) 2633, (Mouse) 14468
regulation of calcium-mediated signaling
negative regulation of T cell receptor signaling pathway
defense response to virus
interferon-gamma-mediated signaling pathway
negative regulation of ERK1 and ERK2 cascade
negative regulation of substrate adhesion-dependent cell spreading
negative regulation of interleukin-2 secretion
regulation of protein localization to plasma membrane
negative regulation of protein localization to plasma membrane
immune system process
cellular response to interferon-beta
defense response to protozoan
adhesion of symbiont to host
defense response to Gram-positive bacterium
cellular response to interferon-gamma
