Fabgennix

GCN2 Polyclonal Antibody, FITC

查看其他16个GCN2抗体

产品信息

GCN2-Y-FITC

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

-

免疫组化 (IHC)

1:50-1:250

-

免疫细胞化学 (ICC/IF)

1:50-1:250

-

酶联免疫吸附实验 (ELISA)

1:10,000

-

免疫沉淀 (IP)

1:50-1:250

-

免疫电镜技术 (IM)

1:50-1:200

-

产品规格

种属反应

Mouse, Rat, Human

宿主/亚型

Chicken / IgY

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide taken within amino acid region 1600-1700 on human GCN2 protein

偶联物

FITC FITC FITC

激发/发射光谱

498/517 nm 查看光谱

形式

Liquid

浓度

0.5-1.5 mg/mL

纯化类型

Affinity chromatography

保存液

proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA

内含物

0.02% sodium azide

保存条件

-20° C, store in dark

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

EIF2AK4 (GCN2) is a metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor-2 in response to low amino acid availability. It plays a role as an activator of the integrated stress response required for adapatation to amino acid starvation. Mutations in the gene lead to pulmonary vennocclusive disease 2.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: eIF-2-alpha kinase GCN2; Eukaryotic translation initiation factor 2-alpha kinase 4; GCN2 eIF2alpha kinase; GCN2-like protein; general control nonderepressible 2; mGCN2

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基因别名: 2610011M03; EIF2AK4; GCN2; KIAA1338; MGCN2; PVOD2

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UniProt ID: (Human) Q9P2K8, (Mouse) Q9QZ05

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Entrez Gene ID: (Human) 440275, (Mouse) 27103, (Rat) 114859

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tRNA binding protein serine/threonine kinase activity eukaryotic translation initiation factor 2alpha kinase activity ATP binding nucleotide binding protein kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups eukaryotic initiation factor eIF2 binding aminoacyl-tRNA synthetase non-receptor serine/threonine protein kinase translational protein

参与通路

positive regulation of defense response to virus by host adaptive immune response T cell activation involved in immune response positive regulation of adaptive immune response regulation of translational initiation protein phosphorylation cell cycle arrest learning long-term memory regulation of translational initiation by eIF2 alpha phosphorylation viral translation negative regulation of translational initiation in response to stress negative regulation of CREB transcription factor activity cellular response to amino acid starvation cellular response to UV eiF2alpha phosphorylation in response to endoplasmic reticulum stress induction by virus of host autophagy negative regulation by host of viral genome replication negative regulation of neuron differentiation negative regulation of translational initiation protein autophosphorylation defense response to virus regulation of feeding behavior regulation of eIF2 alpha phosphorylation by amino acid starvation cellular response to cold positive regulation of translational initiation in response to starvation positive regulation of long-term synaptic potentiation neuron projection extension cellular response to leucine starvation cellular response to starvation positive regulation of gene expression phosphorylation negative regulation of translation endoplasmic reticulum unfolded protein response response to endoplasmic reticulum stress regulation of translational initiation in response to stress