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Immunogen sequence: MAATAVAAAV AGTESAQGPP GPAASLELWL NKATDPSMSE QDWSAIQNFC EQVNTDPNGP THAPWLLAHK IQSPQEKEAL YALTVLEMCM NHCGEKFHSE VAKFRFLNEL IKVLSPKYLG SWATGKVKGR VIEILFSWTV WFPEDIKIRD AYQMLKKQGI IKQDPKLPVD KILPPPSPWP KSSIFDADEE KSKLLTRLLK SNHPEDLQAA NRLIKNLVKE EQEKSEKVSK RVSAVEEVRS HVKVLQEMLS MYRRPGQAPP DQEALQVVYE RCEKLRPTLF RLASDTTDDD DALAEILQAN; Positive Samples: HepG2, Raji, MCF7, THP-1, 22Rv1, Mouse brain, Mouse kidney; Cellular Location: Endosome membrane, Golgi apparatus, Peripheral membrane protein, trans-Golgi network membrane
This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. This family member may play a significant role in cargo molecules regulation and clathrin-coated vesicle assembly.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: ADP-ribosylation factor-binding protein GGA2; gam; Gamma-adaptin-related protein 2; golgi-associated, gamma adaptin ear containing, ARF binding protein 2; Golgi-localized, gamma ear-containing, ARF-binding protein 2; Vear; VHS domain and ear domain of gamma-adaptin; VHS domain and ear domain-containing protein
基因别名: 1200007E24Rik; GGA2; KIAA1080; mKIAA1080; VEAR
UniProt ID: (Human) Q9UJY4, (Mouse) Q6P5E6
Entrez Gene ID: (Human) 23062, (Mouse) 74105