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产品信息
PA5-33580
产品规格
种属反应
Human,
Non-human primate
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic 16 amino acid peptide from internal region of human Ghrelin Receptor.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.1% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2550960
产品详细信息
Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Baboon, Monkey, Marmoset (100%).
靶标信息
Growth hormone secretagogue receptor 1a (GHSR) is a member of the G-protein coupled receptor family. GHSR may play a role in energy homeostasis and regulation of body weight. Two identified transcript variants are expressed in several tissues and are evolutionary conserved in fish and swine. One transcript, 1a, excises an intron and encodes the functional protein; this protein is the receptor for the Ghrelin ligand and defines a neuroendocrine pathway for growth hormone release. The second transcript (1b) retains the intron and does not function as a receptor for Ghrelin; however, it may function to attenuate activity of isoform 1a. Mutations to the gene can cause isolated partial growth hormone deficiency.
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生物信息学
蛋白别名: GH-releasing peptide receptor; Ghrelin receptor; GHRP; Ghrp receptor; GHS receptor; GHS-R; Growth hormone secretagogue receptor type 1
基因别名: GHDP; GHSR
UniProt ID: (Human) Q92847
Entrez Gene ID: (Human) 2693
G-protein coupled receptor signaling pathway
actin polymerization or depolymerization
adult feeding behavior
response to hormone
hormone-mediated signaling pathway
growth hormone secretion
response to food
positive regulation of appetite
negative regulation of interleukin-1 beta production
cellular response to insulin stimulus
positive regulation of multicellular organism growth
negative regulation of tumor necrosis factor biosynthetic process
regulation of hindgut contraction
positive regulation of insulin-like growth factor receptor signaling pathway
negative regulation of interleukin-6 biosynthetic process
positive regulation of fatty acid metabolic process
negative regulation of insulin secretion
decidualization
negative regulation of inflammatory response
regulation of synapse assembly
