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GIPR (extracellular) Antibody (AGR-025-200UL) in IHC (F)
Expression of Gastric inhibitory polypeptide receptor in rat hippocampus - Immunohistochemical staining of perfusion-fixed frozen rat brain sections using Anti-GIPR (extracellular) Antibody (#AGR-025), (1:400), followed by Anti-rabbit-Alexa-488 Antibody . GIPR is expressed (green) in the pyramidal layer (P) of the CA1 rat hippocampal region. Nuclei are labeled with DAPI (blue).
产品信息
AGR-025-200UL
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)EGQTTGELYQRWER,corresponding to amino acid residues 25-38 of rat GIPR, Extracellular, N-terminus
偶联物
Unconjugated
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
GIPR encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: gastric inhibitory peptide receptor; Gastric inhibitory polypeptide receptor; GIP receptor; GIP-R; Glucose-dependent insulinotropic polypeptide receptor
基因别名: GIP-R; Gippr; Gipr; Gm1081; Gm160; RATGIPPR
UniProt ID: (Mouse) Q0P543, (Rat) P43219
Entrez Gene ID: (Mouse) 381853, (Rat) 25024
desensitization of G-protein coupled receptor protein signaling pathway
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
neuropeptide signaling pathway
positive regulation of cAMP biosynthetic process
endocrine pancreas development
positive regulation of insulin secretion
gastric inhibitory peptide signaling pathway
response to calcium ion
response to glucose
response to axon injury
response to fatty acid
