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Invitrogen
GLI3 Recombinant Rabbit Monoclonal Antibody (JG83-39)
高级验证
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
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GLI3 Antibody (MA5-34779) in WB
Western blot was performed using Anti-GLI3 Recombinant Rabbit Monoclonal Antibody (JG83-39) (Product # MA5-34779) and a 200 kDa band corresponding to GLI3 was observed across the cell lines tested along with a non-specific band (*) at ~ 25 kDa. Whole-cell extracts (40 µg lysate) of SW480 (Lane 1), and HeLa (Lane 2) were electrophoresed using NuPAGE™ 3-8% Tris-Acetate Protein Gel (Product # EA0378BOX). Resolved proteins were then transferred onto a nitrocellulose membrane (Product # IB23001) by iBlot® 2 Dry Blotting System (Product # IB2100... View More
产品信息
MA5-34779
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
JG83-39
抗原
Recombinant protein within Human Gli3 aa 1261-1580
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
TBS, pH 7.4, with 40% glycerol, 0.05% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles, store in dark
运输条件
Wet ice
RRID
AB_2848687
产品详细信息
Positive Control: PC-3M.
靶标信息
This gene encodes a protein which belongs to the C2H2-type zinc finger proteins subclass of the Gli family. They are characterized as DNA-binding transcription factors and are mediators of Sonic hedgehog (Shh) signaling. The protein encoded by this gene localizes in the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. Mutations in this gene have been associated with several diseases, including Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, and postaxial polydactyly types A1 and B.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: GLI-Kruppel family member GLI3; GLI3 form of 190 kDa; GLI3 full-length protein; GLI3-190; GLI3FL; glioma-associated oncogene family zinc finger 3; oncogene GLI3; Transcriptional activator GLI3; zinc finger protein GLI3
基因别名: ACLS; GCPS; GLI3; GLI3-190; GLI3FL; PAP-A; PAPA; PAPA1; PAPB; PHS; PPDIV
UniProt ID: (Human) P10071
Entrez Gene ID: (Human) 2737
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
beta-catenin binding
histone acetyltransferase binding
histone deacetylase binding
metal ion binding
DNA-binding transcription factor
negative regulation of transcription from RNA polymerase II promoter
metanephros development
branching involved in ureteric bud morphogenesis
in utero embryonic development
positive regulation of neuroblast proliferation
transcription from RNA polymerase II promoter
smoothened signaling pathway
axon guidance
hindgut morphogenesis
heart development
negative regulation of cell proliferation
anterior/posterior pattern specification
proximal/distal pattern formation
protein processing
optic nerve morphogenesis
hippocampus development
smoothened signaling pathway involved in ventral spinal cord interneuron specification
smoothened signaling pathway involved in spinal cord motor neuron cell fate specification
forebrain dorsal/ventral pattern formation
layer formation in cerebral cortex
forebrain radial glial cell differentiation
lateral ganglionic eminence cell proliferation
melanocyte differentiation
lung development
positive regulation of chondrocyte differentiation
T cell differentiation in thymus
limb morphogenesis
wound healing
positive regulation of protein import into nucleus
odontogenesis of dentin-containing tooth
embryonic digit morphogenesis
negative regulation of apoptotic process
nose morphogenesis
tongue development
response to estrogen
negative thymic T cell selection
negative regulation of neuron differentiation
positive regulation of osteoblast differentiation
negative regulation of smoothened signaling pathway
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of alpha-beta T cell differentiation
negative regulation of alpha-beta T cell differentiation
embryonic digestive tract morphogenesis
embryonic digestive tract development
developmental growth
camera-type eye morphogenesis
embryonic skeletal system morphogenesis
oligodendrocyte differentiation
palate development
frontal suture morphogenesis
lambdoid suture morphogenesis
sagittal suture morphogenesis
mammary gland specification
smoothened signaling pathway involved in dorsal/ventral neural tube patterning
artery development
anterior semicircular canal development
lateral semicircular canal development
cell differentiation involved in kidney development
thymocyte apoptotic process
negative regulation of canonical Wnt signaling pathway
regulation of bone development
