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GNA11 Antibody (PA5-109776) in IHC (P)
Immunohistochemistry analysis of GNA11 in paraffin-embedded human esophageal cancer. Samples were incubated with GNA11 Polyclonal antibody (Product # PA5-109776) using a dilution of 1:100 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
产品信息
PA5-109776
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 250-350 of human GNA11 (NP_0020582)
偶联物
形式
Liquid
浓度
0.46 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2855187
产品详细信息
Immunogen sequence: ESKALFRTII TYPWFQNSSV ILFLNKKDLL EDKILYSHLV DYFPEFDGPQ RDAQAAREFI LKMFVDLNPD SDKIIYSHFT CATDTENIRF VFAAVKDTIL Q
靶标信息
Heterotrimeric guanine nucleotide-binding proteins (G proteins) consist of α, β and γ subunits and mediate the effects of hormones, neurotransmitters, chemokines and sensory stimuli. To date, over 20 known Gα subunits have been classified into four families, Gα(s), Gα(i/o), Gα(q) and Gα(12), based on structural and functional similarities (1,2). Phosphorylation of Tyr356 of Gα(q)/Gα(11) is essential for activation of the G protein, since phenylalanine substitution for Tyr356 changes the interaction of Gα with receptors and abolishes ligand-induced IP3 formation (3).
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: G alpha-11; G-protein subunit alpha-11; Gq class; guanine nucleotide binding protein (G protein), alpha 11 (Gq class); guanine nucleotide regulatory protein G alpha 11; guanine nucleotide-binding protein alpha 11 subunit; Guanine nucleotide-binding protein G(y) subunit alpha; Guanine nucleotide-binding protein subunit alpha-11
基因别名: Dsk7; E430025L19; FBH; FBH2; FHH2; GA11; GNA-11; GNA11; HHC2; HYPOC2
UniProt ID: (Human) P29992, (Mouse) P21278, (Rat) Q9JID2
Entrez Gene ID: (Human) 2767, (Mouse) 14672, (Rat) 81662
skeletal system development
action potential
signal transduction
G-protein coupled acetylcholine receptor signaling pathway
heart development
phototransduction, visible light
entrainment of circadian clock
platelet activation
regulation of melanocyte differentiation
developmental pigmentation
phospholipase C-activating dopamine receptor signaling pathway
cellular response to pH
G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
glutamate receptor signaling pathway
metabolic process
