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产品信息
PA5-70664
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
synthetic peptide directed towards the middle region of human GNA11
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2690088
产品详细信息
This target displays homology in the following species: Dog: 100%; Goat: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%; Zebrafish: 100%
靶标信息
Heterotrimeric guanine nucleotide-binding proteins (G proteins) consist of α, β and γ subunits and mediate the effects of hormones, neurotransmitters, chemokines and sensory stimuli. To date, over 20 known Gα subunits have been classified into four families, Gα(s), Gα(i/o), Gα(q) and Gα(12), based on structural and functional similarities (1,2). Phosphorylation of Tyr356 of Gα(q)/Gα(11) is essential for activation of the G protein, since phenylalanine substitution for Tyr356 changes the interaction of Gα with receptors and abolishes ligand-induced IP3 formation (3).
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生物信息学
蛋白别名: G alpha-11; G-protein subunit alpha-11; Gq class; guanine nucleotide binding protein (G protein), alpha 11 (Gq class); Guanine nucleotide-binding protein G(y) subunit alpha; Guanine nucleotide-binding protein subunit alpha-11
基因别名: Dsk7; E430025L19; FBH; FBH2; FHH2; GA11; GNA-11; GNA11; HHC2; HYPOC2
UniProt ID: (Human) P29992, (Mouse) P21278
Entrez Gene ID: (Human) 2767, (Mouse) 14672
skeletal system development
action potential
signal transduction
G-protein coupled acetylcholine receptor signaling pathway
heart development
phototransduction, visible light
entrainment of circadian clock
platelet activation
regulation of melanocyte differentiation
developmental pigmentation
phospholipase C-activating dopamine receptor signaling pathway
cellular response to pH
G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
glutamate receptor signaling pathway
