Invitrogen

GNA11 Polyclonal Antibody

高级验证

This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.

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说明书

实验方案

技术支持

说明书

实验方案

技术支持

抗体检测数据 (5)
高级验证 (1)

GNA11 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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GNA11 Antibody (PA5-76678) in IHC (P)

Immunohistochemistry analysis of GNA11 in paraffin-embedded human esophageal cancer. Samples were incubated with GNA11 polyclonal antibody (Product # PA5-76678) using a dilution of 1:150. Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.

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GNA11 Antibody — Antibody specificity was demonstrated by siRNA mediated knockdown of target protein. MDA-MB-231 cells were transfected with GNA11 siRNA and a decrease in signal intensity for both 42 kDa (Fig.b) and 28 kD (Fig.c) was observed in western blot application using Anti-GNA11 Polyclonal Antibody (Product # PA5-76678). {KD}

产品信息

PA5-76678

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

免疫组化（石蜡） (IHC (P))

1:50-1:200

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant full length Human GNA11.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 50% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2720405

产品详细信息

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

靶标信息

Heterotrimeric guanine nucleotide-binding proteins (G proteins) consist of α, β and γ subunits and mediate the effects of hormones, neurotransmitters, chemokines and sensory stimuli. To date, over 20 known Gα subunits have been classified into four families, Gα(s), Gα(i/o), Gα(q) and Gα(12), based on structural and functional similarities (1,2). Phosphorylation of Tyr356 of Gα(q)/Gα(11) is essential for activation of the G protein, since phenylalanine substitution for Tyr356 changes the interaction of Gα with receptors and abolishes ligand-induced IP3 formation (3).

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: G alpha-11; G-protein subunit alpha-11; Gq class; guanine nucleotide binding protein (G protein), alpha 11 (Gq class); guanine nucleotide regulatory protein G alpha 11; guanine nucleotide-binding protein alpha 11 subunit; Guanine nucleotide-binding protein G(y) subunit alpha; Guanine nucleotide-binding protein subunit alpha-11

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基因别名: Dsk7; E430025L19; FBH; FBH2; FHH2; GA11; GNA-11; GNA11; HHC2; HYPOC2

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UniProt ID: (Human) P29992, (Mouse) P21278, (Rat) Q9JID2

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Entrez Gene ID: (Human) 2767, (Mouse) 14672, (Rat) 81662

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