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GNAQ Antibody (PA5-77989) in IHC (P)
GNAQ Polyclonal Antibody detects GNAQ protein at cell membrane and cytoplasm in rat intestine by immunohistochemical analysis. Sample: Paraffin-embedded rat intestine. GNAQ Polyclonal Antibody (Product # PA5-77989) diluted at 1:500. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min.
产品信息
PA5-77989
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the center region of human GNAQ. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 0.1M glycine, 10% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2735864
产品详细信息
Positive Control: 3xFlag-human GNAQ-transfected 293T
Predicted Reactivity: Zebrafish (93%), Xenopus laevis (96%), Dog (100%), Pig (100%), Chicken (98%), Rhesus Monkey (100%), Bovine (100%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
Guanine nucleotide-binding proteins are a family of heterotrimeric proteins that couple cell surface, 7-transmembrane domain receptors to intracellular signaling pathways. Receptor activation catalyzes the exchange of GTP for GDP bound to the inactive G protein alpha subunit resulting in a conformational change and dissociation of the complex. The G protein alpha and beta-gamma subunits are capable of regulating various cellular effectors. Activation is terminated by a GTPase intrinsic to the G-alpha subunit. G-alpha-q is the alpha subunit of one of the heterotrimeric GTP-binding proteins that mediates stimulation of phospholipase C-beta.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: G alpha q; guanine nucleotide binding protein (G protein), q polypeptide; guanine nucleotide binding protein alpha q subunit; guanine nucleotide binding protein, alpha q polypeptide; guanine nucleotide regulatory protein G alpha q; Guanine nucleotide-binding protein alpha-q; Guanine nucleotide-binding protein G(q) subunit alpha; heterotrimeric guanine nucleotide-binding protein alpha q subunit
基因别名: 1110005L02Rik; 6230401I02Rik; AA408290; AW060788; CMC1; Dsk1; Dsk10; G-ALPHA-q; Galphaq; GAQ; GNAQ; Gq; GqI; SWS
UniProt ID: (Human) P50148, (Rat) P82471, (Mouse) P21279
Entrez Gene ID: (Human) 2776, (Rat) 81666, (Mouse) 14682
GTPase activity
signal transducer activity
GTPase activator activity
protein binding
GTP binding
G-protein beta/gamma-subunit complex binding
type 2A serotonin receptor binding
metal ion binding
G-protein coupled receptor binding
protein complex binding
nucleotide binding
guanyl nucleotide binding
heterotrimeric G-protein
skeletal system development
action potential
negative regulation of protein kinase activity
adenylate cyclase-activating G-protein coupled receptor signaling pathway
activation of phospholipase C activity
G-protein coupled acetylcholine receptor signaling pathway
glutamate receptor signaling pathway
heart development
blood coagulation
phototransduction, visible light
entrainment of circadian clock
post-embryonic development
neuron remodeling
forebrain neuron development
platelet activation
regulation of catenin import into nucleus
maternal behavior
embryonic digit morphogenesis
positive regulation of GTPase activity
regulation of melanocyte differentiation
developmental pigmentation
protein stabilization
phospholipase C-activating dopamine receptor signaling pathway
G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
metabolic process
positive regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of potassium ion transport
positive regulation of smooth muscle cell proliferation
signal transduction
