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A suggested positive control for this product is plasma membranes from rat cerebrum.
The Gb5 protein is a G protein subunit present predominantly in the central nervous system. This protein appears to be expressed in two forms, one found in the brain of 39 kDa and one found in the retina of 44 kDa. It has also been found that Gb5 associates tightly with RGS7, a member of the superfamily of negative regulators of G protein signaling. These complexes have been localized to most regions of the brain, whereas Gb1-4 exhibit no observable colocalization with RGS7, despite their widespread codistribution throughout similar neuronal networks. This antibody is specific for a peptide sequence within the D1 blade which is not found in the Gb's 1-4.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: flail; flailer; G protein, beta subunit 5L; G protein, beta-5 subunit; GBB5; Gbeta5; guanine nucleotide binding protein (G protein), beta 5; guanine nucleotide binding protein (G protein), beta polypeptide 5; guanine nucleotide binding protein, beta 5; Guanine nucleotide-binding protein subunit beta-5; guanine nucleotide-binding protein, beta subunit 5L; guanine nucleotide-binding protein, beta-5 subunit; hug; Transducin beta chain 5
基因别名: flr; GB5; Gbeta5; GBS; GNB5
UniProt ID: (Human) O14775, (Mouse) P62881, (Rat) P62882
Entrez Gene ID: (Human) 10681, (Mouse) 14697, (Rat) 83579
分子生物学功能: heterotrimeric G-protein