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GPIHBP1 Antibody (PA5-89108) in WB
Western blot analysis of GPIHBP1 in extracts of various cell lines. Samples were incubated with GPIHBP1 Polyclonal antibody (Product # PA5-89108) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
产品信息
PA5-89108
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 50-151 of human GPIHBP1 (NP_8354662)
偶联物
形式
Liquid
浓度
1.68 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2805360
产品详细信息
Immunogen sequence: ETNRLPGGRS RVLLRCYTCK SLPRDERCNL TQNCSHGQTC TTLIAHGNTE SGLLTTHSTW CTDSCQPITK TVEGTQVTMT CCQSSLCNVP PWQSSRVQDP TG; Positive Samples: U-87MG, LO2; Cellular Location: Apical cell membrane, Basolateral cell membrane, Cell membrane, Extracellular side, GPI-anchor, Lipid-anchor, Peripheral membrane protein
靶标信息
GPI-anchored HDL-binding protein 1 (Gpihbp1) is a novel protein that may be involved in the regulation of the delivery of fats to cells for energy and storage. Digested fats travel to the small intestine, where they are packaged into chylomicrons (particles filled with triglycerides). Chylomicrons then travel through the bloodstream and deliver triglycerides to tissues that are hungry for fuel or to adipose tissue for energy storage. Triglycerides are broken down or hydrolyzed by the enzyme lipoprotein lipase (LpL). The triglyceride breakdown products are then taken up and used by cells. Gpihbp1 is the molecule in capillaries that facilitates the capture of chylomicrons and facilitates the interaction with LpL. It has been shown that fats in the bloodstream are not readily metabolized in the absence of GPIHBP1.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: endothelial cell LPL transporter; Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1; GPI anchored high density lipoprotein binding protein 1; GPI-anchored HDL-binding protein 1; GPI-HBP1; HDLBP; HDLBP1; High density lipoprotein-binding protein 1
基因别名: GPI-HBP1; GPIHBP1; HBP1; HYPL1D
UniProt ID: (Human) Q6P3T2
Entrez Gene ID: (Human) 338328
lipid transport
intracellular protein transport
protein import
protein localization to cell surface
cholesterol homeostasis
transcytosis
protein stabilization
positive regulation of lipoprotein lipase activity
triglyceride homeostasis
response to heparin
protein transmembrane transport
positive regulation of chylomicron remnant clearance
