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产品信息
PA5-121014
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 24-160 of human GPLD1 (NP_001494.2).
偶联物
形式
Liquid
浓度
0.75 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2914586
产品详细信息
Positive test controls include: Human plasma, Mouse plasma, Mouse liver, Rat plasma. The target is usually found in the following locations: Secreted.
Immunogen sequence: CGLSTHVEIG HRALEFLQLH NGRVNYRELL LEHQDAYQAG IVFPDCFYPS ICKGGKFHDV SESTHWTPFL NASVHYIREN YPLPWEKDTE KLVAFLFGIT SHMAADVSWH SLGLEQGFLR TMGAIDFHGS YSEAHSA
靶标信息
GPLD1 is expressed in numerous tissues and cells and specifically cleaves GPI-anchored proteins. Liver has the highest level of GPI-PLD expression and is the primary organ contributing to GPLD1 in the serum. GPLD1 is abundant in serum in which it associates with polipoproteins AI and AIV. Increased serum GPLD1 is associated with insulin resistance and elevated serum triglycerides. Many surface proteins are attached to eukaryotic cell membranes via glycosylphosphatidylinositol (GPI) anchors that are covalently bound to the C-terminus of the protein and cleavage of the GPI moiety by GPLD1, only enzyme known that cleavage GPI anchor, may represent a means of regulating attachment of these proteins to the cell surface, or alternatively, their release into the extracellular environment.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Glycoprotein phospholipase D; Glycosyl-phosphatidylinositol-specific phospholipase D; glycosylphosphatidylinositol phospholipase D; glycosylphosphatidylinositol specific phospholipase D1, isoform 2; GPI-PLD; GPI-specific phospholipase D; MGC22590; Phosphatidylinositol-glycan-specific phospholipase D; PI-G PLD
基因别名: 6330541J12Rik; AW546131; GPIPLD; GPIPLDM; GPLD1; PIGPLD; PIGPLD1; PLD
UniProt ID: (Human) P80108, (Rat) Q8R2H5
Entrez Gene ID: (Human) 2822, (Rat) 291132, (Mouse) 14756
ossification
cell migration involved in sprouting angiogenesis
chondrocyte differentiation
complement receptor mediated signaling pathway
GPI anchor release
negative regulation of cell proliferation
insulin receptor signaling pathway
response to glucose
positive regulation of endothelial cell migration
positive regulation of alkaline phosphatase activity
positive regulation of triglyceride biosynthetic process
negative regulation of triglyceride catabolic process
positive regulation of glucose metabolic process
positive regulation of high-density lipoprotein particle clearance
cellular response to insulin stimulus
cellular response to drug
hematopoietic stem cell migration
positive regulation of insulin secretion involved in cellular response to glucose stimulus
positive regulation of apoptotic process
positive regulation of cytolysis
phosphatidylcholine metabolic process
positive regulation of membrane protein ectodomain proteolysis
positive regulation of secretion
transepithelial transport
cellular response to calcium ion
cellular response to cholesterol
cellular response to triglyceride
cellular response to pH
hematopoietic stem cell migration to bone marrow
regulation of cellular response to insulin stimulus
cellular response to inorganic substance
cellular response to iron(II) ion
