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产品信息
PA5-32839
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic 20 amino acid peptide from C-terminal cytoplasmic domain of human C5L2.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.1% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2550301
产品详细信息
Percent identity with other species by BLAST analysis: Human (100%); Gorilla (95%); Monkey (90%); Marmoset (85%).
For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
靶标信息
C5AR2 is an orphan member that belongs to anaphylatoxin receptor family. It is a seven transmembrane G-protein-coupled receptor consisting of an N-terminal N-glycosylation site, several conserved cysteines and several potential C-terminal phosphorylation sites. It binds to C5a and C5a-des-Arg and serves as a highly regulated scavenger receptor with a negative modulatory influence on C5aR-mediated inflammation. Northern Blot analysis suggests it is co- expressed along with C5aR in different tissues and cells including neutrophils/macrophages, mast cells, dendritic cells, brain, lung, heart, kidney, liver, ovary and testis.
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生物信息学
蛋白别名: C5a anaphylatoxin chemotactic receptor 2; C5a anaphylatoxin chemotactic receptor C5L2; Complement component 5a receptor 2; G protein-coupled receptor 77; G protein-coupled receptor C5L2; G-protein coupled receptor 77
基因别名: C5AR2; C5L2; GPF77; GPR77
UniProt ID: (Human) Q9P296
Entrez Gene ID: (Human) 27202
chemotaxis
inflammatory response
G-protein coupled receptor signaling pathway
regulation of complement activation
negative regulation of tumor necrosis factor production
positive regulation of epithelial cell proliferation
positive regulation of ERK1 and ERK2 cascade
negative regulation of neutrophil chemotaxis
negative regulation of interleukin-6 secretion
regulation of interleukin-8 secretion
