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Peptide sequence: YFYLHDYAKA LEYHHHDLTL ARTIGDQLGE AKASGNLGNT LKVLGNFDEA
Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 86%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 93%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
The protein encoded by this gene belongs to a family of proteins that modulate activation of G proteins, which transduce extracellular signals received by cell surface receptors into integrated cellular responses. The N-terminal half of this protein contains 10 copies of leu-gly-asn repeat, and the C-terminal half contains 4 GoLoco motifs, which are involved in guanine nucleotide exchange. This protein may play a role in neuroblast division and in the development of normal hearing. Mutations in this gene are associated with autosomal recessive nonsyndromic deafness.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: G-protein signalling modulator 2 (AGS3-like, C. elegans); G-protein-signaling modulator 2; HGNC:29501; LGN protein; Mosaic protein LGN
基因别名: CMCS; DFNB82; GPSM2; LGN; PINS
UniProt ID: (Human) P81274
Entrez Gene ID: (Human) 29899