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GRK1 Antibody (PA5-13725) in IHC (P)
Immunohistochemistry analysis of GRK1 in formalin-fixed and paraffin-embedded human cancer tissue. Samples were incubated with GRK1 polyclonal antibody (Product # PA5-13725) which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepato... View More
产品信息
PA5-13725
产品规格
种属反应
Human,
Mouse
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide between 520-550 amino acids from the C-terminal region of human GRK1
偶联物
形式
Liquid
纯化类型
Size-exclusion - Dialysis, Ammonium sulfate precipitation
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2115610
靶标信息
GRK1 is a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinases. GRK1 mediates rapid desensitization of rod photoreceptors to light by catalyzing phosphorylation of the visual pigment rhodopsin which leads to its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2). GRK1 can be phosphorylated by PKA and this reduces the ability of GRK1 to phosphorylate rhodopsin in vitro. It is speculated that phosphorylation of GRK1 by PKA in vivo occurs in the dark when cAMP levels in photoreceptor cells are elevated.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: G protein-coupled receptor kinase 1; G-protein receptor kinase 1; GRK 1a/b; GRK1a; rhodopsin kinase; Rhodopsin kinase GRK1; RK
基因别名: GPRK1; GRK1; RHOK; RK
UniProt ID: (Human) Q15835
Entrez Gene ID: (Human) 6011, (Mouse) 24013
protein kinase activity
G-protein coupled receptor kinase activity
ATP binding
rhodopsin kinase activity
nucleotide binding
protein serine/threonine kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
visual perception
regulation of G-protein coupled receptor protein signaling pathway
rhodopsin mediated signaling pathway
regulation of rhodopsin mediated signaling pathway
protein autophosphorylation
protein phosphorylation
signal transduction
photoreceptor cell morphogenesis
response to light stimulus
phosphorylation
termination of G-protein coupled receptor signaling pathway
positive regulation of phosphorylation
negative regulation of apoptotic process
response to stimulus
post-embryonic retina morphogenesis in camera-type eye
