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产品信息
PA5-32858
产品规格
种属反应
Bat,
Bovine,
Chicken,
Horse,
Human,
Mouse,
Non-human primate,
Pig,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic 15 amino acid peptide from internal region of human GRK5.
偶联物
Unconjugated
形式
Liquid
浓度
0.35 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.1% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2550319
产品详细信息
Percent identity with other species by BLAST analysis: Human, Gibbon, Monkey, Marmoset, Mouse, Rat, Bat, Bovine, Panda, Horse, Pig, Opossum, Turkey, Chicken, Platypus (100%); Orangutan, Dog, Elephant, Xenopus (93%).
For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
靶标信息
GRK5 is a serine/threonine kinase that regulates the activity of a variety of G protein-coupled receptors and the motility of polymorphonuclear leukocytes. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Alpha-CP4; FP2025; G protein-coupled receptor kinase 5; G protein-coupled receptor kinase GRK5; GRK; GRK-pan; Pan-GRK; Poly(rC)-binding protein 4
基因别名: 1200003L19Rik; AlphaCP-4; GPRK5; GRK5; Pcbp4
UniProt ID: (Bovine) P43249, (Human) P34947, (Mouse) Q8VEB1, (Rat) Q62833, (Mouse) P57724
Entrez Gene ID: (Bovine) 281801, (Human) 2869, (Chicken) 423929, (Horse) 100065919, (Pig) 100152937, (Mouse) 14773, (Rat) 59075, (Mouse) 59092
protein serine/threonine kinase activity
G-protein coupled receptor kinase activity
ATP binding
lipid binding
beta-adrenergic receptor kinase activity
protein kinase C binding
protein binding
phospholipid binding
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
nucleic acid binding
DNA binding
RNA binding
poly(A) RNA binding
RNA metabolism protein
non-receptor serine/threonine protein kinase
apoptotic process
tachykinin receptor signaling pathway
positive regulation of cell proliferation
Wnt signaling pathway
negative regulation of apoptotic process
fat cell differentiation
protein autophosphorylation
regulation of cell cycle
desensitization of G-protein coupled receptor protein signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
regulation of G-protein coupled receptor protein signaling pathway
response to drug
protein phosphorylation
signal transduction
phosphorylation
termination of G-protein coupled receptor signaling pathway
negative regulation of mRNA splicing, via spliceosome
