Search Thermo Fisher Scientific
Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Elephant, Panda, Dog, Bat, Horse, Rabbit, Pig (100%) Bovine (94%).
Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: bombesin receptor 2; Gastrin-releasing peptide receptor; GRP receptor; GRP-preferring bombesin receptor; GRP-R
基因别名: BB2; BB2R; GRPR
UniProt ID: (Human) P30550
Entrez Gene ID: (Rabbit) 100344857, (Pig) 100517439, (Dog) 491754, (Human) 2925, (Horse) 100056400