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Invitrogen
GSR Polyclonal Antibody
Product Details
PA5-29945
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fragment corresponding to a region within amino acids 164 and 403 of Human Glutathione reductase
Conjugate
Unconjugated
Form
Liquid
Concentration
1.21 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2547419
Product Specific Information
Recommended positive controls: HCT116, mouse eye, mouse brain, PC-12, Rat-2.
Predicted reactivity: Mouse (85%), Rat (87%), Bovine (84%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: epididymis luminal protein 75; epididymis secretory sperm binding protein Li 122m; glutathione reductase; glutathione reductase 1; Glutathione reductase, mitochondrial; glutathione S-reductase; GR; GRase
Gene Aliases: AI325518; D8Ertd238e; GLUR; Gr-1; Gr1; GRD1; GSR; HEL-75; HEL-S-122m
UniProt ID: (Human) P00390, (Mouse) P47791
Entrez Gene ID: (Human) 2936, (Mouse) 14782, (Rat) 116686
glutathione-disulfide reductase activity
electron carrier activity
flavin adenine dinucleotide binding
NADP binding
oxidoreductase activity
oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
protein homodimerization activity
glutathione binding
oxidoreductase
reductase
metabolite interconversion enzyme
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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